Structural basis for ovarian tumor domain-containing protein 1 (otu1) binding to p97/valosin-containing protein (vcp)

Su Jin Kim, Jinhong Cho, Eun Joo Song, Soo Jin Kim, Ho Min Kim, Kyung Eun Lee, Se Won Suh, Eunice Eun Kyeong Kim

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: Ovarian tumor domain-containing protein 1 (OTU1) acts as a deubiquitinating enzyme in the endoplasmic reticulum-associated degradation (ERAD) pathway by associating with valosin-containing protein (VCP). Results: One OTU1 binds to a VCP hexamer with a KD of 0.71 M. Conclusion: The 39GYPP42 (S3/S4) loop of OTU1 is critical for interaction with VCP. Significance: This is the first structural study of VCP and OTU1 complex.

Original languageEnglish
Pages (from-to)12264-12274
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number18
DOIs
StatePublished - 2014

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