Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder

Christen M. Deveney; Megan E. Connolly; Sarah E. Jenkins; Pilyoung Kim; Stephen J. Fromm; Melissa A. Brotman; Daniel S. Pine; Ellen Leibenluft

doi:10.1016/j.pnpbp.2012.02.014

Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder

Christen M. Deveney, Megan E. Connolly, Sarah E. Jenkins, Pilyoung Kim, Stephen J. Fromm, Melissa A. Brotman, Daniel S. Pine, Ellen Leibenluft

Department of Psychology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD. Methods: 19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3. T scanner. Results: Children at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups. Conclusions: Striatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.

Original language	English
Pages (from-to)	127-133
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.pnpbp.2012.02.014
State	Published - 7 Aug 2012

Bibliographical note

Funding Information:
This work was supported by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health . The authors have no conflicts to disclose. We thank the children and families for their participation which made this research possible. We also thank the staff of the Emotion and Development Branch at NIMH.

Keywords

Bipolar disorder
Magnetic resonance imaging
Motor inhibition
Population at risk

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10.1016/j.pnpbp.2012.02.014

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title = "Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder",

abstract = "Background: A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD. Methods: 19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3. T scanner. Results: Children at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups. Conclusions: Striatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.",

keywords = "Bipolar disorder, Magnetic resonance imaging, Motor inhibition, Population at risk",

author = "Deveney, {Christen M.} and Connolly, {Megan E.} and Jenkins, {Sarah E.} and Pilyoung Kim and Fromm, {Stephen J.} and Brotman, {Melissa A.} and Pine, {Daniel S.} and Ellen Leibenluft",

note = "Funding Information: This work was supported by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health . The authors have no conflicts to disclose. We thank the children and families for their participation which made this research possible. We also thank the staff of the Emotion and Development Branch at NIMH. ",

year = "2012",

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doi = "10.1016/j.pnpbp.2012.02.014",

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T1 - Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder

AU - Deveney, Christen M.

AU - Connolly, Megan E.

AU - Jenkins, Sarah E.

AU - Kim, Pilyoung

AU - Fromm, Stephen J.

AU - Brotman, Melissa A.

AU - Pine, Daniel S.

AU - Leibenluft, Ellen

N1 - Funding Information: This work was supported by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health . The authors have no conflicts to disclose. We thank the children and families for their participation which made this research possible. We also thank the staff of the Emotion and Development Branch at NIMH.

PY - 2012/8/7

Y1 - 2012/8/7

N2 - Background: A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD. Methods: 19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3. T scanner. Results: Children at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups. Conclusions: Striatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.

AB - Background: A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD. Methods: 19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3. T scanner. Results: Children at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups. Conclusions: Striatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.

KW - Bipolar disorder

KW - Magnetic resonance imaging

KW - Motor inhibition

KW - Population at risk

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Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder

Abstract

Bibliographical note

Keywords

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