TY - JOUR
T1 - Strategies against methicillin-resistant Staphylococcus aureus persisters
AU - Kim, Wooseong
AU - Hendricks, Gabriel L.
AU - Tori, Katerina
AU - Fuchs, Beth B.
AU - Mylonakis, Eleftherios
N1 - Publisher Copyright:
© 2018 Newlands Press.
PY - 2018/4
Y1 - 2018/4
N2 - Chronic Staphylococcus aureus infections are complicated by frequent relapses not only from the development of drug resistance to conventional antibiotics, but also through the formation of persister bacterial cells. Bacterial persisters are in a transient, metabolically inactive state, making conventional antibiotics that target essential cellular growth processes ineffective, resulting in high clinical failure rates of antibiotic chemotherapy. The development of new antibiotics against persistent S. aureus is an urgent issue. Over the last decade, new strategies to identify S. aureus persister-active compounds have been proposed. This review summarizes the proposed targets, antipersister compounds and innovative methods that may augment conventional antibiotics against S. aureus persisters. The reviewed antipersister strategies can be summarized as two broad categories; directly targeting growth-independent targets and potentiating existing, ineffective antibiotics by aiding uptake or accessibility.
AB - Chronic Staphylococcus aureus infections are complicated by frequent relapses not only from the development of drug resistance to conventional antibiotics, but also through the formation of persister bacterial cells. Bacterial persisters are in a transient, metabolically inactive state, making conventional antibiotics that target essential cellular growth processes ineffective, resulting in high clinical failure rates of antibiotic chemotherapy. The development of new antibiotics against persistent S. aureus is an urgent issue. Over the last decade, new strategies to identify S. aureus persister-active compounds have been proposed. This review summarizes the proposed targets, antipersister compounds and innovative methods that may augment conventional antibiotics against S. aureus persisters. The reviewed antipersister strategies can be summarized as two broad categories; directly targeting growth-independent targets and potentiating existing, ineffective antibiotics by aiding uptake or accessibility.
KW - MRSA
KW - antibiotics
KW - drug discover
KW - persisters
UR - http://www.scopus.com/inward/record.url?scp=85046245485&partnerID=8YFLogxK
U2 - 10.4155/fmc-2017-0199
DO - 10.4155/fmc-2017-0199
M3 - Review article
C2 - 29569952
AN - SCOPUS:85046245485
SN - 1756-8919
VL - 10
SP - 779
EP - 794
JO - Future Medicinal Chemistry
JF - Future Medicinal Chemistry
IS - 7
ER -