Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists

Kyoungjin Shin, Jungwook Chin, Dongyup Hahn, Jaehwan Lee, Hoosang Hwang, Dong Hwan Won, Jungyeob Ham, Hyukjae Choi, Eunsoo Kang, Hiyoung Kim, Moon Kyeong Ju, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC 50's 14 and 15 μM.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
Issue number5
StatePublished - Apr 2012

Bibliographical note

Funding Information:
This work was supported by the Marine Biotechnology Program, Ministry of Land, Transport and Maritime Affairs. S-J. Nam, K. Shin, J. Chin, H. Hwang and H. Choi were in part supported by the BK21 program, Ministry of Education, Science and Technology, Korea. The authors thank K.N. Maloney for her help in preparing this article.


  • Cholestasis
  • Dendronephthya gigantea
  • Farnesoid X-activated receptor


Dive into the research topics of 'Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists'. Together they form a unique fingerprint.

Cite this