Stereoselective Synthesis of d -5-Homo-4-selenoribose as a Versatile Intermediate for 4′-Selenonucleosides

Gyudong Kim, Yoojin Choi, Pramod K. Sahu, Jinha Yu, Shuhao Qu, Dongjoo Lee, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Stereoselective synthesis of d-5-homo-4-selenoribose, serving as a versatile intermediate for the synthesis of 4′-selenonucleosides 12a-c, was accomplished using Sharpless asymmetric epoxidation, regioselective cleavage of the α,β-epoxide, and stereoselective reduction of the ketone as the key steps.

Original languageEnglish
Pages (from-to)4636-4639
Number of pages4
JournalOrganic Letters
Volume17
Issue number18
DOIs
StatePublished - 18 Sep 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

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