@article{f1cfba282cac4fffa8a64f4848670ad2,
title = "Stereoselective Synthesis of a Ceramide Transporter Protein (CERT)-Dependent Ceramide-Trafficking Inhibitor, (1R,3S)-HPA-12, via Gold(I)-Catalyzed Cyclization of a Propargylic N-Hydroxylamine",
abstract = "A ceramide transporter protein (CERT)-dependent ceramide-trafficking inhibitor, HPA-12, is efficiently synthesized using gold(I)-catalyzed cyclization of a propargylic N-hydroxylamine, which is prepared via a stereoselective nitrone-alkyne addition reaction. The resulting 4-isoxazoline is converted into a syn-1,3-amino alcohol through stereoselective reduction and reductive ring opening.",
keywords = "4-isoxazoline, gold, HPA-12, nitrone, stereoselective synthesis",
author = "Bandari Chandrasekhar and Sewon Ahn and Ryu, {Jae Sang}",
note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A2A2A01004511 and NRF-2014R1A2A1A11050112). Publisher Copyright: {\textcopyright} Georg Thieme VerlagStuttgart · New York.",
year = "2017",
month = apr,
day = "1",
doi = "10.1055/s-0036-1588369",
language = "English",
volume = "49",
pages = "1569--1574",
journal = "Synthesis (Germany)",
issn = "0039-7881",
publisher = "Georg Thieme Verlag",
number = "7",
}