Stereoselective recognition of amino alcohols and amino acids by carbonylurea-and carbonyguanidinium-based imine receptors

Raju Nandhakumar, Yun Soo Ahn, Hoe Jin Yoon, Kwan Mook Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

New receptors 1-3 that bind stereoselectively amino alcohols and convert chirality of amino acidsvia imine bond formation were synthesized. The receptors have uryl (1), thiouryl (2) and guanidinium (3) groups all with additional phenylcarbonyl motifs, which are effective hydrogen bonding donors and play a key role in the stereoselective recognitions. The stereoselectivities were measured from the integration of 1H NMR peaks. Compound 1 and 2 showed the stereoselectivities for the imine formation with amino alcohols (KR/KS) in the range of 2 ~ 4, and compound 3 in the range of 4 ~ 8. Chirality conversion efficienciesof 1-3 for amino acids, i.e. D/L ratio at equilibrium, are in the range of 1.5 ~ 5.6, showing a little higher efficiency with 3. The additional phenylcarbonyl motifs in 1-3 were revealed not to contribute to significant enhancement of the selectivities.

Original languageEnglish
Pages (from-to)2938-2942
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume30
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Amino acid
  • Amino alcohol
  • Chirality conversion
  • Imine receptor
  • Stereoselective recognition

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