SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

Dongyeop Lee; Dae Eun Jeong; Heehwa G. Son; Yasuyo Yamaoka; Hyunmin Kim; Keunhee Seo; Abdul Aziz Khan; Tae Young Roh; Dae Won Moon; Youngsook Lee; Seung Jae V. Lee

doi:10.1101/gad.266304.115

SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

Dongyeop Lee, Dae Eun Jeong, Heehwa G. Son, Yasuyo Yamaoka, Hyunmin Kim, Keunhee Seo, Abdul Aziz Khan, Tae Young Roh, Dae Won Moon, Youngsook Lee, Seung Jae V. Lee

Department of Life Science

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator- 15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.

Original language	English
Pages (from-to)	2490-2503
Number of pages	14
Journal	Genes and Development
Volume	29
Issue number	23
DOIs	https://doi.org/10.1101/gad.266304.115
State	Published - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 Lee et al.

Keywords

Aging
C. elegans
Fat
Glucose
MDT-15
SREBP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1101/gad.266304.115

Cite this

@article{20a0e0f7e7254303852fdf416378ea4b,

title = "SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat",

abstract = "Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator- 15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.",

keywords = "Aging, C. elegans, Fat, Glucose, MDT-15, SREBP",

author = "Dongyeop Lee and Jeong, {Dae Eun} and Son, {Heehwa G.} and Yasuyo Yamaoka and Hyunmin Kim and Keunhee Seo and Khan, {Abdul Aziz} and Roh, {Tae Young} and Moon, {Dae Won} and Youngsook Lee and Lee, {Seung Jae V.}",

note = "Publisher Copyright: {\textcopyright} 2015 Lee et al.",

year = "2015",

month = dec,

day = "1",

doi = "10.1101/gad.266304.115",

language = "English",

volume = "29",

pages = "2490--2503",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "23",

}

TY - JOUR

T1 - SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

AU - Lee, Dongyeop

AU - Jeong, Dae Eun

AU - Son, Heehwa G.

AU - Yamaoka, Yasuyo

AU - Kim, Hyunmin

AU - Seo, Keunhee

AU - Khan, Abdul Aziz

AU - Roh, Tae Young

AU - Moon, Dae Won

AU - Lee, Youngsook

AU - Lee, Seung Jae V.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator- 15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.

AB - Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator- 15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.

KW - Aging

KW - C. elegans

KW - Fat

KW - Glucose

KW - MDT-15

KW - SREBP

UR - http://www.scopus.com/inward/record.url?scp=84957831219&partnerID=8YFLogxK

U2 - 10.1101/gad.266304.115

DO - 10.1101/gad.266304.115

M3 - Article

C2 - 26637528

AN - SCOPUS:84957831219

SN - 0890-9369

VL - 29

SP - 2490

EP - 2503

JO - Genes and Development

JF - Genes and Development

IS - 23

ER -

SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this