SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

Dongyeop Lee, Dae Eun Jeong, Heehwa G. Son, Yasuyo Yamaoka, Hyunmin Kim, Keunhee Seo, Abdul Aziz Khan, Tae Young Roh, Dae Won Moon, Youngsook Lee, Seung Jae V. Lee

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator- 15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.

Original languageEnglish
Pages (from-to)2490-2503
Number of pages14
JournalGenes and Development
Volume29
Issue number23
DOIs
StatePublished - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 Lee et al.

Keywords

  • Aging
  • C. elegans
  • Fat
  • Glucose
  • MDT-15
  • SREBP

Fingerprint

Dive into the research topics of 'SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat'. Together they form a unique fingerprint.

Cite this