SRC activates TAZ for intestinal tumorigenesis and regeneration

Mi Ran Byun, Jun Ha Hwang, A. Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Eun Sook Hwang, Jeong Ho Hong

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Proto-oncogene tyrosine-protein kinase Src (cSRC) is involved in colorectal cancer (CRC) development and damage-induced intestinal regeneration, although the cellular mechanisms involved are poorly understood. Here, we report that transcriptional coactivator with PDZ binding domain (TAZ) is activated by cSRC, regulating CRC cell proliferation and tumor formation, where cSRC overexpression increases TAZ expression in CRC cells. In contrast, knockdown of cSRC decreases TAZ expression. Additionally, direct phosphorylation of TAZ at Tyr316 by cSRC stimulates nuclear localization and facilitates transcriptional enhancer factor TEF-3 (TEAD4)-mediated transcription. However, a TAZ phosphorylation mutant significantly decreased cell proliferation, wound healing, colony forming, and tumor formation. In a CRC mouse model, ApcMin/+, activated SRC expression was associated with increased TAZ expression in polyps and TAZ depletion decreased polyp formation. Moreover, intestinal TAZ knockout mice had intestinal regeneration defects following γ-irradiation. Finally, significant correspondence between SRC activation and TAZ overexpression was observed in CRC patients. These results suggest that TAZ is a critical factor for SRC-mediated intestinal tumor formation and regeneration.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalCancer Letters
StatePublished - 1 Dec 2017

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program of NRF funded by the Ministry of Education ( 2015R1A5A1009024 and 2016R1D1A1B03930490 ), Republic of Korea. This work was also supported by a Korea University grant.

Publisher Copyright:
© 2017 Elsevier B.V.


  • APC
  • Colorectal cancer
  • Regeneration
  • SRC
  • TAZ


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