Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development

Chang Hwan Choi, Ji Seon Jeong, Bo Im Yoo, You Xun Jin, Dong Cheul Moon, Hwan Soo Yoo, Seikwan Oh, Seon Pyo Hong, Yong Moon Lee

Research output: Contribution to journalArticlepeer-review


The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase (Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.

Original languageEnglish
Pages (from-to)502-506
Number of pages5
JournalArchives of Pharmacal Research
Issue number4
StatePublished - 30 Apr 2007


  • Chicken embryo
  • Development
  • Sphingosine
  • Sphingosine 1-phosphate
  • Sphk activity


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