Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development

Chang Hwan Choi; Ji Seon Jeong; Bo Im Yoo; You Xun Jin; Dong Cheul Moon; Hwan Soo Yoo; Seikwan Oh; Seon Pyo Hong; Yong Moon Lee

doi:10.1007/BF02980226

Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development

Chang Hwan Choi, Ji Seon Jeong, Bo Im Yoo, You Xun Jin, Dong Cheul Moon, Hwan Soo Yoo, Seikwan Oh, Seon Pyo Hong, Yong Moon Lee

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase (Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.

Original language	English
Pages (from-to)	502-506
Number of pages	5
Journal	Archives of Pharmacal Research
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/BF02980226
State	Published - 30 Apr 2007

Bibliographical note

Funding Information:
This work was supported by a Korean Research Foun-

Keywords

Chicken embryo
Development
Sphingosine
Sphingosine 1-phosphate
Sphk activity

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10.1007/BF02980226

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title = "Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development",

abstract = "The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase (Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.",

keywords = "Chicken embryo, Development, Sphingosine, Sphingosine 1-phosphate, Sphk activity",

author = "Choi, {Chang Hwan} and Jeong, {Ji Seon} and Yoo, {Bo Im} and Jin, {You Xun} and Moon, {Dong Cheul} and Yoo, {Hwan Soo} and Seikwan Oh and Hong, {Seon Pyo} and Lee, {Yong Moon}",

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doi = "10.1007/BF02980226",

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AU - Choi, Chang Hwan

AU - Jeong, Ji Seon

AU - Yoo, Bo Im

AU - Jin, You Xun

AU - Moon, Dong Cheul

AU - Yoo, Hwan Soo

AU - Oh, Seikwan

AU - Hong, Seon Pyo

AU - Lee, Yong Moon

N1 - Funding Information: This work was supported by a Korean Research Foun-

PY - 2007/4/30

Y1 - 2007/4/30

N2 - The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase (Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.

AB - The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase (Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.

KW - Chicken embryo

KW - Development

KW - Sphingosine

KW - Sphingosine 1-phosphate

KW - Sphk activity

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JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 4

ER -

Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development

Abstract

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Keywords

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