Drug metabolites have been monitored with various types of newly developed techniques and/or combination of common analytical methods, which could provide a great deal of information on metabolite profiling. Because it is not easy to analyze whole drug metabolites qualitatively and quantitatively, a single solution of analytical techniques is combined in a multilateral manner to cover the widest range of drug metabolites. Mass-based spectroscopic analysis of drug metabolites has been expanded with the help of other parameter-based methods. The current development of metabolism studies through contemporary pharmaceutical research are reviewed with an overview on conventionally used spectroscopic methods. Several technical approaches for conducting drug metabolic profiling through spectroscopic methods are discussed in depth.
Bibliographical noteFunding Information:
This work is supported in part by Grants provided by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2017R1D1A1B03030723), the Industrial Core Technology Development Program (10067427), funded by the Ministry of Trade, Industry and Energy (MOTIE), High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea (316058-3, 315063-3), the Functional Districts of the Science Belt support program, Ministry of Science, ICT and Future Planning, Republic of Korea (2017K000017) and the Ewha Womans University Research Grant of 2017 and 2018. This study also partly supported by the GRRC program of Gyeonggi province (GRRC-CHA2017-A01, Discovery and Analysis of Regional Specialized Resources and Operation of Regional Research Service Center). The authors confirm that this article content has no conflicts of interest.
© 2018, The Pharmaceutical Society of Korea.
- Circular dichroism
- Drug metabolites
- Infrared spectroscopy
- Mass spectrometry
- Nuclear magnetic resonance
- Raman spectroscopy
- Surface plasmon resonance
- Ultraviolet–visible spectroscopy