Spectroscopic methods to analyze drug metabolites

Jong Jae Yi, Kyeongsoon Park, Won Je Kim, Jin Kyu Rhee, Woo Sung Son

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Drug metabolites have been monitored with various types of newly developed techniques and/or combination of common analytical methods, which could provide a great deal of information on metabolite profiling. Because it is not easy to analyze whole drug metabolites qualitatively and quantitatively, a single solution of analytical techniques is combined in a multilateral manner to cover the widest range of drug metabolites. Mass-based spectroscopic analysis of drug metabolites has been expanded with the help of other parameter-based methods. The current development of metabolism studies through contemporary pharmaceutical research are reviewed with an overview on conventionally used spectroscopic methods. Several technical approaches for conducting drug metabolic profiling through spectroscopic methods are discussed in depth.

Original languageEnglish
Pages (from-to)355-371
Number of pages17
JournalArchives of Pharmacal Research
Volume41
Issue number4
DOIs
StatePublished - 1 Apr 2018

Keywords

  • Circular dichroism
  • Drug metabolites
  • Infrared spectroscopy
  • Mass spectrometry
  • Nuclear magnetic resonance
  • Raman spectroscopy
  • Spectroscopy
  • Surface plasmon resonance
  • Ultraviolet–visible spectroscopy

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