SoxD transcription factors: Multifaceted players of neural development

Eun Hye Ji, Jaesang Kim

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter- specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalInternational Journal of Stem Cells
Volume9
Issue number1
DOIs
StatePublished - 2016

Keywords

  • Neural development
  • Neural stem cell
  • Sox13
  • Sox5
  • Sox6
  • SoxD

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