Abstract
SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter- specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.
| Original language | English |
|---|---|
| Pages (from-to) | 3-8 |
| Number of pages | 6 |
| Journal | International Journal of Stem Cells |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2016 |
Bibliographical note
Funding Information:This study was supported by grants from the Ministry of Health & Welfare, Republic of Korea (A120262) and from the Ministry of Science, ICT and Future Planning via National Research Foundation via National Research Foundation (2012M3A9B4028766 & 2013M3C7A1056563). Support also came from the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (grant No.2015K1A4A3047851).
Keywords
- Neural development
- Neural stem cell
- Sox13
- Sox5
- Sox6
- SoxD