In the exploitation of nanozymes possessing intrinsic enzyme-like activities for cancer therapy, minor focus has been devoted to plasmonic nanostructures with localized surface plasmon resonance (LSPR)-driven properties. Here, we report the application of unique peroxidase-mimicking plasmonic photo-nanozymes coupling tumor-microenvironment-responsive reactive oxygen species generation with photothermal effect for effective combinatorial therapy. The well-defined anisotropic photo-nanozyme is synthesized by selectively depositing Pd nanoparticles on the tips of gold nanobypyramids. Intrinsic peroxidase-like properties with 1.5-fold-activity enhancement under photoexcitation are ascribed to a Pd-induced hot electrons/holes separation with efficient H2O2 decomposition. The LSPR-induced photocatalytic/photothermal combinatorial effects are remarkably enhanced upon H2O2 addition, critically suppressing the cell survival rate under near-infrared light. An effective decomposition of cell-signaling H2O2 additionally reveals prominent expression hindrance of vascular endothelial growth factor and hypoxia-inducible factor 1α. Our seminal findings uncover an interrelation between LSPR-induced phenomena and biomimetic fingerprints, valuable to overcome the shortcomings of conventional photodynamic therapy.
Bibliographical noteFunding Information:
This work was supported by National Research Foundation of Korea Grant funded by the Korean Government [NRF-2020R1A2C3003958 and 2017M3A9D8029942], by Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education [2020R1A6C101B194], by Basic Science Research Program (Priority Research Institute) through the NRF funded by the Ministry of Education [2021R1A6A1A10039823] and by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT [2018M 3D1A1058536]. The authors would also like to thank the Korean Basic Science Institute (KBSI) at the Western Seoul center for EPR measurements.
© 2021 The Korean Society of Industrial and Engineering Chemistry
- Multimodal therapy
- Peroxidase-like activity
- Photodynamic cancer therapy