Sophisticated plasmon-enhanced photo-nanozyme for anti-angiogenic and tumor-microenvironment-responsive combinatorial photodynamic and photothermal cancer therapy

Subin Yu, Dohyub Jang, Swarup Kumar Maji, Kyungwha Chung, June Sang Lee, Filipe Marques Mota, Jianfang Wang, Sehoon Kim, Dong Ha Kim

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In the exploitation of nanozymes possessing intrinsic enzyme-like activities for cancer therapy, minor focus has been devoted to plasmonic nanostructures with localized surface plasmon resonance (LSPR)-driven properties. Here, we report the application of unique peroxidase-mimicking plasmonic photo-nanozymes coupling tumor-microenvironment-responsive reactive oxygen species generation with photothermal effect for effective combinatorial therapy. The well-defined anisotropic photo-nanozyme is synthesized by selectively depositing Pd nanoparticles on the tips of gold nanobypyramids. Intrinsic peroxidase-like properties with 1.5-fold-activity enhancement under photoexcitation are ascribed to a Pd-induced hot electrons/holes separation with efficient H2O2 decomposition. The LSPR-induced photocatalytic/photothermal combinatorial effects are remarkably enhanced upon H2O2 addition, critically suppressing the cell survival rate under near-infrared light. An effective decomposition of cell-signaling H2O2 additionally reveals prominent expression hindrance of vascular endothelial growth factor and hypoxia-inducible factor 1α. Our seminal findings uncover an interrelation between LSPR-induced phenomena and biomimetic fingerprints, valuable to overcome the shortcomings of conventional photodynamic therapy.

Original languageEnglish
Pages (from-to)106-116
Number of pages11
JournalJournal of Industrial and Engineering Chemistry
Volume104
DOIs
StatePublished - 25 Dec 2021

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea Grant funded by the Korean Government [NRF-2020R1A2C3003958 and 2017M3A9D8029942], by Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education [2020R1A6C101B194], by Basic Science Research Program (Priority Research Institute) through the NRF funded by the Ministry of Education [2021R1A6A1A10039823] and by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT [2018M 3D1A1058536]. The authors would also like to thank the Korean Basic Science Institute (KBSI) at the Western Seoul center for EPR measurements.

Publisher Copyright:
© 2021 The Korean Society of Industrial and Engineering Chemistry

Keywords

  • Multimodal therapy
  • Nanozymes
  • Peroxidase-like activity
  • Photodynamic cancer therapy
  • Plasmonics

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