Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP)

Jiwon Jung, Seonhyung Ryu, In A. Ki, Hyun Ae Woo, Kyunglim Lee

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Na,K-ATPase is an ionic pump that regulates the osmotic equilibrium and membrane potential of cells and also functions as a signal transducer. The interaction of Na,K-ATPase with translationally controlled tumor protein (TCTP) results, among others, in the inhibition of the former’s pump activity and in the initiation of manifold biological and pathological phenomena. These phenomena include hypertension and cataract development in TCTP-overexpressing transgenic mice, as well as the induction of tumorigenesis signaling pathways and the activation of Src that ultimately leads to cell proliferation and migration. This review attempts to collate the biological effects of Na,K-ATPase and TCTP interaction and suggests that this interaction has the potential to serve as a possible therapeutic target for selected diseases.

Original languageEnglish
Article number1657
JournalInternational Journal of Molecular Sciences
Volume19
Issue number6
DOIs
StatePublished - 4 Jun 2018

Keywords

  • Autophagy
  • Hypertension
  • K-ATPase
  • Na
  • Translationally controlled tumor protein
  • Tumorigenesis

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