Solvent-free preparation of caprolactone oligomer microspheres

Jisun Lee; Saemi Oh; Min Kyung Joo; Byeongmoon Jeong

doi:10.1016/j.jpcs.2007.09.016

Solvent-free preparation of caprolactone oligomer microspheres

Jisun Lee, Saemi Oh, Min Kyung Joo, Byeongmoon Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Caprolactone (M_n∼3000 Da, melting point ∼46 °C) oligomer microspheres were prepared by an organic solvent-free process, and were investigated as a delivery system of a hydrophobic model drug (estradiol). The drug was dissolved in a polycaprolactone/poly(ethylene glycol-b-caprolactone) mixture at 50 °C, which was above the melting points of both polymers. The mixture was homogenized in water for 10 min at 50 °C, then it was quenched in the ice bath for 10 min to harden the microsphere. The polycaprolactone of the poly(ethylene glycol-b-caprolactone) coaggregated into the microsphere, and poly(ethylene glycol) formed a shell layer of the microsphere that protects the microsphere from interparticle aggregation during the hardening process of the microsphere in water. The size of microsphere could be controlled by the amount of polycaprolactone relative to poly(ethylene glycol-b-caprolactone). Estradiol release from the microsphere was investigated.

Original language	English
Pages (from-to)	1596-1599
Number of pages	4
Journal	Journal of Physics and Chemistry of Solids
Volume	69
Issue number	5-6
DOIs	https://doi.org/10.1016/j.jpcs.2007.09.016
State	Published - May 2008

Bibliographical note

Funding Information:
This work was supported by the SRC program of MOST/KOSEF through the center for Intelligent NanoBio Materials at Ewha Womans University (Grant: R11-2005-008-0000-0) and Basic Research Promotion Fund (KRF-2006-005-J04003).

Keywords

A. Polymers
D. Microstructure
D. Surface properties

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10.1016/j.jpcs.2007.09.016

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title = "Solvent-free preparation of caprolactone oligomer microspheres",

abstract = "Caprolactone (Mn∼3000 Da, melting point ∼46 °C) oligomer microspheres were prepared by an organic solvent-free process, and were investigated as a delivery system of a hydrophobic model drug (estradiol). The drug was dissolved in a polycaprolactone/poly(ethylene glycol-b-caprolactone) mixture at 50 °C, which was above the melting points of both polymers. The mixture was homogenized in water for 10 min at 50 °C, then it was quenched in the ice bath for 10 min to harden the microsphere. The polycaprolactone of the poly(ethylene glycol-b-caprolactone) coaggregated into the microsphere, and poly(ethylene glycol) formed a shell layer of the microsphere that protects the microsphere from interparticle aggregation during the hardening process of the microsphere in water. The size of microsphere could be controlled by the amount of polycaprolactone relative to poly(ethylene glycol-b-caprolactone). Estradiol release from the microsphere was investigated.",

keywords = "A. Polymers, D. Microstructure, D. Surface properties",

author = "Jisun Lee and Saemi Oh and Joo, {Min Kyung} and Byeongmoon Jeong",

note = "Funding Information: This work was supported by the SRC program of MOST/KOSEF through the center for Intelligent NanoBio Materials at Ewha Womans University (Grant: R11-2005-008-0000-0) and Basic Research Promotion Fund (KRF-2006-005-J04003). ",

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AU - Lee, Jisun

AU - Oh, Saemi

AU - Joo, Min Kyung

AU - Jeong, Byeongmoon

N1 - Funding Information: This work was supported by the SRC program of MOST/KOSEF through the center for Intelligent NanoBio Materials at Ewha Womans University (Grant: R11-2005-008-0000-0) and Basic Research Promotion Fund (KRF-2006-005-J04003).

PY - 2008/5

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N2 - Caprolactone (Mn∼3000 Da, melting point ∼46 °C) oligomer microspheres were prepared by an organic solvent-free process, and were investigated as a delivery system of a hydrophobic model drug (estradiol). The drug was dissolved in a polycaprolactone/poly(ethylene glycol-b-caprolactone) mixture at 50 °C, which was above the melting points of both polymers. The mixture was homogenized in water for 10 min at 50 °C, then it was quenched in the ice bath for 10 min to harden the microsphere. The polycaprolactone of the poly(ethylene glycol-b-caprolactone) coaggregated into the microsphere, and poly(ethylene glycol) formed a shell layer of the microsphere that protects the microsphere from interparticle aggregation during the hardening process of the microsphere in water. The size of microsphere could be controlled by the amount of polycaprolactone relative to poly(ethylene glycol-b-caprolactone). Estradiol release from the microsphere was investigated.

AB - Caprolactone (Mn∼3000 Da, melting point ∼46 °C) oligomer microspheres were prepared by an organic solvent-free process, and were investigated as a delivery system of a hydrophobic model drug (estradiol). The drug was dissolved in a polycaprolactone/poly(ethylene glycol-b-caprolactone) mixture at 50 °C, which was above the melting points of both polymers. The mixture was homogenized in water for 10 min at 50 °C, then it was quenched in the ice bath for 10 min to harden the microsphere. The polycaprolactone of the poly(ethylene glycol-b-caprolactone) coaggregated into the microsphere, and poly(ethylene glycol) formed a shell layer of the microsphere that protects the microsphere from interparticle aggregation during the hardening process of the microsphere in water. The size of microsphere could be controlled by the amount of polycaprolactone relative to poly(ethylene glycol-b-caprolactone). Estradiol release from the microsphere was investigated.

KW - A. Polymers

KW - D. Microstructure

KW - D. Surface properties

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ER -

Solvent-free preparation of caprolactone oligomer microspheres

Abstract

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Keywords

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