Solvent-free preparation of caprolactone oligomer microspheres

Jisun Lee, Saemi Oh, Min Kyung Joo, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Caprolactone (Mn∼3000 Da, melting point ∼46 °C) oligomer microspheres were prepared by an organic solvent-free process, and were investigated as a delivery system of a hydrophobic model drug (estradiol). The drug was dissolved in a polycaprolactone/poly(ethylene glycol-b-caprolactone) mixture at 50 °C, which was above the melting points of both polymers. The mixture was homogenized in water for 10 min at 50 °C, then it was quenched in the ice bath for 10 min to harden the microsphere. The polycaprolactone of the poly(ethylene glycol-b-caprolactone) coaggregated into the microsphere, and poly(ethylene glycol) formed a shell layer of the microsphere that protects the microsphere from interparticle aggregation during the hardening process of the microsphere in water. The size of microsphere could be controlled by the amount of polycaprolactone relative to poly(ethylene glycol-b-caprolactone). Estradiol release from the microsphere was investigated.

Original languageEnglish
Pages (from-to)1596-1599
Number of pages4
JournalJournal of Physics and Chemistry of Solids
Volume69
Issue number5-6
DOIs
StatePublished - May 2008

Keywords

  • A. Polymers
  • D. Microstructure
  • D. Surface properties

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