Solid-state and solvent-free synthesis of azines, pyrazoles, and pyridazinones using solid hydrazine

Byeongno Lee, Philjun Kang, Kyu Hyung Lee, Jaeheung Cho, Wonwoo Nam, Won Koo Lee, Nam Hwi Hur

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Azines, pyrazoles, and pyridazinones were isolated as the sole products in high yields (>97%) by grinding solid hydrazine (H3N +NHCO2-) with di-carbonyl compounds or by their reaction in the absence of solvent. Neither catalysts nor additives were needed to promote the reactions. The solid-state and solvent-free reactions proceeded under ambient conditions and did not produce any wastes other than water and carbon dioxide. They are operationally easy, environmentally safe, and readily scalable, allowing for highly selective synthesis of compounds containing the hydrazine motif. Copyright

Original languageEnglish
Pages (from-to)1384-1388
Number of pages5
JournalTetrahedron Letters
Volume54
Issue number11
DOIs
StatePublished - 13 Mar 2013

Keywords

  • Azines
  • Pyrazoles
  • Pyridazinones
  • Solid state reaction
  • Solvent-free conditions

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