Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial

Hyun Gun Kim; Kyu Chan Huh; Hoon Sup Koo; Seong Eun Kim; Jin Oh Kim; Tae Il Kim; Hyun Soo Kim; Seung Jae Myung; Dong Il Park; Jeong Eun Shin; Dong Hoon Yang; Suck Ho Lee; Ji Sung Lee; Chang Kyun Lee; Dong Kyung Chang; Young Eun Joo; Jae Myung Cha; Sung Pil Hong; Hyo Jong Kim

doi:10.5009/gnl14010

Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial

Hyun Gun Kim, Kyu Chan Huh, Hoon Sup Koo, Seong Eun Kim, Jin Oh Kim, Tae Il Kim, Hyun Soo Kim, Seung Jae Myung, Dong Il Park, Jeong Eun Shin, Dong Hoon Yang, Suck Ho Lee, Ji Sung Lee, Chang Kyun Lee, Dong Kyung Chang, Young Eun Joo, Jae Myung Cha, Sung Pil Hong, Hyo Jong Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

Original language	English
Pages (from-to)	494-501
Number of pages	8
Journal	Gut and Liver
Volume	9
Issue number	4
DOIs	https://doi.org/10.5009/gnl14010
State	Published - 1 Jul 2015

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Publisher Copyright:
© This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Bowel preparation
Colonoscopy
Polyethylene glycols
Sodium picosulfate with magnesium citrate

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10.5009/gnl14010

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Kim, H. G., Huh, K. C., Koo, H. S., Kim, S. E., Kim, J. O., Kim, T. I., Kim, H. S., Myung, S. J., Park, D. I., Shin, J. E., Yang, D. H., Lee, S. H., Lee, J. S., Lee, C. K., Chang, D. K., Joo, Y. E., Cha, J. M., Hong, S. P., & Kim, H. J. (2015). Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial. Gut and Liver, 9(4), 494-501. https://doi.org/10.5009/gnl14010

@article{70cc1eaa24764825ba1290457fbedba5,

title = "Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial",

abstract = "Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.",

keywords = "Bowel preparation, Colonoscopy, Polyethylene glycols, Sodium picosulfate with magnesium citrate",

author = "Kim, {Hyun Gun} and Huh, {Kyu Chan} and Koo, {Hoon Sup} and Kim, {Seong Eun} and Kim, {Jin Oh} and Kim, {Tae Il} and Kim, {Hyun Soo} and Myung, {Seung Jae} and Park, {Dong Il} and Shin, {Jeong Eun} and Yang, {Dong Hoon} and Lee, {Suck Ho} and Lee, {Ji Sung} and Lee, {Chang Kyun} and Chang, {Dong Kyung} and Joo, {Young Eun} and Cha, {Jae Myung} and Hong, {Sung Pil} and Kim, {Hyo Jong}",

note = "Publisher Copyright: {\textcopyright} This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2015",

month = jul,

day = "1",

doi = "10.5009/gnl14010",

language = "English",

volume = "9",

pages = "494--501",

journal = "Gut and Liver",

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Kim, HG, Huh, KC, Koo, HS, Kim, SE, Kim, JO, Kim, TI, Kim, HS, Myung, SJ, Park, DI, Shin, JE, Yang, DH, Lee, SH, Lee, JS, Lee, CK, Chang, DK, Joo, YE, Cha, JM, Hong, SP & Kim, HJ 2015, 'Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial', Gut and Liver, vol. 9, no. 4, pp. 494-501. https://doi.org/10.5009/gnl14010

Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial. / Kim, Hyun Gun; Huh, Kyu Chan; Koo, Hoon Sup et al.
In: Gut and Liver, Vol. 9, No. 4, 01.07.2015, p. 494-501.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation

T2 - A multicenter randomized single-blinded trial

AU - Kim, Hyun Gun

AU - Huh, Kyu Chan

AU - Koo, Hoon Sup

AU - Kim, Seong Eun

AU - Kim, Jin Oh

AU - Kim, Tae Il

AU - Kim, Hyun Soo

AU - Myung, Seung Jae

AU - Park, Dong Il

AU - Shin, Jeong Eun

AU - Yang, Dong Hoon

AU - Lee, Suck Ho

AU - Lee, Ji Sung

AU - Lee, Chang Kyun

AU - Chang, Dong Kyung

AU - Joo, Young Eun

AU - Cha, Jae Myung

AU - Hong, Sung Pil

AU - Kim, Hyo Jong

N1 - Publisher Copyright: © This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

AB - Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

KW - Bowel preparation

KW - Colonoscopy

KW - Polyethylene glycols

KW - Sodium picosulfate with magnesium citrate

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U2 - 10.5009/gnl14010

DO - 10.5009/gnl14010

M3 - Article

C2 - 25287163

AN - SCOPUS:84936995958

SN - 1976-2283

VL - 9

SP - 494

EP - 501

JO - Gut and Liver

JF - Gut and Liver

IS - 4

ER -

Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial

Abstract

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Keywords

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