Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide- mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia

Hee Sun Kim, So Young Whang, Moon Sook Woo, Jin Sun Park, Won Ki Kim, Inn Oc Han

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

In the present study, we demonstrate that sodium butyrate repressed IFN-γ-induced expression of iNOS and TNF-α, but had little effect on LPS-induced expression in BV2 murine microglial cells. Sodium butyrate significantly inhibited NF-κB binding and NF-κB-mediated transcription induced by IFN-γ, suggesting that the anti-inflammatory effect of sodium butyrate is mediated via specific inhibition of the NF-κB pathway. IFN-γ is a major stimulator of innate and adaptive immune response. Thus, the specific down-regulation of IFN-γ-induced microglial activation by sodium butyrate may provide potential therapeutic strategies for a variety of inflammatory diseases in the central nervous system.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalJournal of Neuroimmunology
Volume151
Issue number1-2
DOIs
StatePublished - Jun 2004

Keywords

  • IFN-γ
  • iNOS
  • Microglia
  • NF-κB1
  • Sodium butyrate

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