@article{d40babf084a04c3fa5bbe24bb4955e31,
title = "Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress",
abstract = "Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cell survival under metabolic stress. Mechanistically, Snail regulates glycolytic activity via repression of phosphofructokinase, platelet (PFKP), a major isoform of cancer-specific phosphofructokinase-1 (PFK-1), an enzyme involving the first rate-limiting step of glycolysis. The suppression of PFKP switches the glucose flux towards PPP, generating NADPH with increased metabolites of oxidative PPP. Functionally, dynamic regulation of PFKP significantly potentiates cancer cell survival under metabolic stress and increases metastatic capacities in vivo. Further, knockdown of PFKP rescues metabolic reprogramming and cell death induced by loss of Snail. Thus, the Snail-PFKP axis plays an important role in cancer cell survival via regulation of glucose flux between glycolysis and PPP.",
author = "Kim, {Nam Hee} and Cha, {Yong Hoon} and Jueun Lee and Lee, {Seon Hyeong} and Yang, {Ji Hye} and Yun, {Jun Seop} and Cho, {Eunae Sandra} and Xianglan Zhang and Miso Nam and Nami Kim and Yuk, {Young Su} and Cha, {So Young} and Yoonmi Lee and Ryu, {Joo Kyung} and Sunghyouk Park and Cheong, {Jae Ho} and Kang, {Sang Won} and Kim, {Soo Youl} and Hwang, {Geum Sook} and Yook, {Jong In} and Kim, {Hyun Sil}",
note = "Funding Information: This work was supported by grants from the National Research Foundation of Korea (NRF-2012M3A9B2052523, NRF-2014R1A2A1A05004670, NRF-2016R1E1A1A01942724) funded by the Korea government (MSIP), a grant from the National Research Foundation of Korea (NRF-2014R1A6A3A04055110) funded by the Korea government (MOE), and a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (1420310). This work was also supported by the by the National Research Council of Science & Technology (CAP-2012-2-KBSI), and the Korea Basic Science Institute (C36705). S.Y. Kim was supported by a grant from the National Cancer Center of Korea (NCC1410670). Publisher Copyright: {\textcopyright} The Author(s) 2017.",
year = "2017",
month = feb,
day = "8",
doi = "10.1038/ncomms14374",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}