Smoking history and clinical features of cluster headache: Results from the korean cluster headache registry

Pil Wook Chung, Byung Su Kim, Jeong Wook Park, Jong Hee Sohn, Mi Ji Lee, Byung Kun Kim, Min Kyung Chu, Jin Young Ahn, Yun Ju Choi, Tae Jin Song, Dae Woong Bae, Daeyoung Kim, Jae Moon Kim, Soo Kyoung Kim, Kwang Yeol Park, Jae Myun Chung, Heui Soo Moon, Kyungmi Oh, Chin Sang Chung, Soo Jin Cho

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background and Purpose Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry. Methods Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers. Results This study enrolled 250 patients who were diagnosed with CH, of which 152 (60.8%) were ever-smokers and 98 (39.2%) were never-smokers. The age at CH onset was significantly lower in the never-smoker group than in the ever-smoker group [27.1±12.9 years vs. 30.6± 10.9 years (mean±standard deviation), p=0.024]. Seasonal rhythmicity (58.1% vs. 44.7%, p= 0.038) and triptan responsiveness (100% vs. 85.1%, p=0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1). Conclusions Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Issue number2
StatePublished - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 Korean Neurological Association.


  • Cluster headache
  • Sex differences
  • Smoking


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