Small Bowel Necrosis Associated with Catastrophic Antiphospholipid Syndrome: A Case Report

Hyun Ae Lee, Seong Eun Kim, Do Woung Jung, Ju Ran Byeon, A. Reum Choe, Chung Hyun Tae, Chang Mo Moon, Hye Kyung Jung, Ki Nam Shim, Sung Ae Jung

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1 Scopus citations


Catastrophic antiphospholipid syndrome is a highly fatal condition characterized by widespread thromboembolism subsequent to a triggering factor (e.g., infection, trauma, and neoplasia) in antiphospholipid antibody-positive patients. This paper reports a case of a 29-year-old male without the underlying disease who developed extensive mesenteric thromboembolism and jejunal necrosis during the treatment for acute enteritis. The patient's condition was improved with low-molecular-weight heparin and an intravenous Ig treatment with emergency surgery. The serum antiphospholipid (anticardiolipin IgM) and lupus anticoagulant antibody tests showed positive results. Acute infectious enterocolitis is generally considered a mild disease. On the other hand, aggressive evaluation and treatment should be considered if the clinical conditions do not improve and deteriorate rapidly despite appropriate antibiotic treatment because of the possibility of acute immunological complications, such as catastrophic antiphospholipid syndrome.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Issue number6
StatePublished - 25 Jun 2021


  • Catastrophic antiphospholipid syndrome
  • Enterocolitis
  • Intestine
  • Mesenteric ischemia
  • Surgical procedure
  • small


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