Slow eroding biodegradable multiblock poloxamer copolymers

Jin Sun Ahn, Ju Myung Suh, Minyung Lee, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Biodegradable multiblock poloxamers (BMPs) with gel duration of 8h to several weeks were prepared by varying their molecular weights from 4000 to 40 000 g mol-1. The molecular weight of the BMP was controlled by changing the poloxamer to coupling agent ratio. Assuming a micelle packing model of the BMP gel, as in the case of a poloxamer gel, the micelle properties and critical gel concentration of BMPs were investigated on the basis of the scaling concept. The findings suggest that the control of molecular weight by hydrolyzable groups can be a facile approach to optimize the gel properties for biomedical applications.

Original languageEnglish
Pages (from-to)842-847
Number of pages6
JournalPolymer International
Volume54
Issue number5
DOIs
StatePublished - May 2005

Keywords

  • Block copolymer
  • Micelle
  • Poloxamer
  • Sol-gel transition
  • Thermoreversible gel

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