Skin wound healing effects of (+)-syringaresinol from ginseng berry

Jee hyun Hwang, Yeonsoo Kang, Heui Jin Park, Seolyeong Kim, Su Hyun Lee, Hangun Kim, Sang Jip Nam, Kyung Min Lim

Research output: Contribution to journalArticlepeer-review


Background: Ginseng has been used as a traditional medicine and functional cosmetic ingredients for many years. Recent studies have focused on the potential biological effects of the ginseng berry and its ingredients. (+)-Syringaresinol (SYR) is enriched in ginseng berry and its beneficial effects on the skin have been recently reported. However, little is known about the its effects on the wound healing process of skin. Methods: Here, we evaluated the skin wound healing effect of (+)-SYR using the human fibroblast Hs68 cell and ex vivo pig and human skin tissue model. Scratch wound test and hydrogen peroxide (HPO) induce chemical wound model were employed. Results: (+)-SYR promoted the migration and proliferation of Hs68 cells without significant cytotoxicity at the tested concentrations. Especially, in ex vivo pig and human skin tissue, HPO-induced chemical wound was recovered almost completely by (+)-SYR. In line with the finding in Hs68, the protein expression levels of TGF-β and PCNA, a proliferation marker were increased, demonstrating the beneficial effects of (+)-SYR on skin wound repair. Conclusion: Collectively, we demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair.

Original languageEnglish
Pages (from-to)654-661
Number of pages8
JournalJournal of Ginseng Research
Issue number5
StatePublished - Sep 2023

Bibliographical note

Funding Information:
This work was supported by grants from National Research Foundation of Korea (Grant No. 2021R1A2C2013347 and MSIT 2018R1A5A2025286 ).

Publisher Copyright:
© 2023


  • (+)-Syringaresinol
  • Ginseng berry
  • Panax ginseng
  • Wound healing


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