Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2

Eunju Jang; Serin Lee; Jiyu Han; Jun Chang

doi:10.1038/s41541-025-01186-x

Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2

Eunju Jang
, Serin Lee
, Jiyu Han
, Jun Chang

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We have developed adenovector-based vaccines targeting G and M2 protein of respiratory syncytial virus. Single intranasal vaccination induced robust G protein-specific IgG and IgA responses, as well as M2-specific CD8⁺ T-cell immunity, and provided protection against RSV A and B infection. These findings suggest that this vaccine combination holds promising potential for effective RSV prevention.

Original language	English
Article number	139
Journal	npj Vaccines
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41541-025-01186-x
State	Published - Dec 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41541-025-01186-x

Cite this

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title = "Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2",

abstract = "We have developed adenovector-based vaccines targeting G and M2 protein of respiratory syncytial virus. Single intranasal vaccination induced robust G protein-specific IgG and IgA responses, as well as M2-specific CD8+ T-cell immunity, and provided protection against RSV A and B infection. These findings suggest that this vaccine combination holds promising potential for effective RSV prevention.",

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AU - Han, Jiyu

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AB - We have developed adenovector-based vaccines targeting G and M2 protein of respiratory syncytial virus. Single intranasal vaccination induced robust G protein-specific IgG and IgA responses, as well as M2-specific CD8+ T-cell immunity, and provided protection against RSV A and B infection. These findings suggest that this vaccine combination holds promising potential for effective RSV prevention.

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Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2

Abstract

Bibliographical note

UN SDGs

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