Simple synthesis and biological evaluation of flocoumafen and its structural isomers

Jae Chul Jung, Soyong Jang, Seikwan Oh, Oee Sook Park

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 μM in vitro, while no significant effect for neurotoxicity in cultured cortical neurons.

Original languageEnglish
Pages (from-to)833-838
Number of pages6
JournalJournal of Chemical Sciences
Issue number6
StatePublished - Nov 2010

Bibliographical note

Funding Information:
This work was supported by the research grant of the Chungbuk National University in 2009.


  • Coupling reaction, no-generation
  • Flocoumafen
  • Intramolecular ring cyclization
  • Neurotoxicity


Dive into the research topics of 'Simple synthesis and biological evaluation of flocoumafen and its structural isomers'. Together they form a unique fingerprint.

Cite this