Abstract
Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 μM in vitro, while no significant effect for neurotoxicity in cultured cortical neurons.
Original language | English |
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Pages (from-to) | 833-838 |
Number of pages | 6 |
Journal | Journal of Chemical Sciences |
Volume | 122 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2010 |
Bibliographical note
Funding Information:This work was supported by the research grant of the Chungbuk National University in 2009.
Keywords
- Coupling reaction, no-generation
- Flocoumafen
- Intramolecular ring cyclization
- Neurotoxicity