@article{a246b750ce1b472fb8c3d0b43acbc165,
title = "Silver-impregnated negative-pressure wound therapy for the treatment of lower-extremity open wounds: A prospective randomized clinical study",
abstract = "OBJECTIVE To investigate the antibacterial efficacy of silver-impregnated negative-pressure wound therapy (NPWT) in lower-extremity acute traumatic wounds. METHODS Open contaminated wounds caused by high-velocity trauma in the lower extremities were randomly allocated into two groups. The wounds in the control and experimental groups were treated with conventional NPWT (n = 31) and silver-impregnated NPWT (n = 35), respectively. MAIN OUTCOME MEASURES Serial bacterial cultures were obtained from the participants' wounds, polyurethane foam, and suction tubes weekly during the 4-week follow-up to identify bacteria and follow their conversions. MAIN RESULTS Bacterial colonization rates in the silver NPWT group were generally lower than those in the conventional NPWT group, and the difference increased with time. For methicillin-resistant Staphylococcus aureus colonization, wounds treated with silver-impregnated NPWT showed a significant reduction in bacterial load compared with those treated with conventional NPWT. CONCLUSIONS Silver-impregnated NPWT effectively decreases bacterial load in open contaminated wounds of the lower extremities. It can be used as a temporizing measure to manage bacterial colonization while patients and wounds are being prepared for final wound reconstruction.",
keywords = "bacterial load, lower extremity, negative-pressure wound therapy, open wounds, silver, wound dressing",
author = "Hahn, {Hyung Min} and Jae Lee and Woo, {Kyong Je} and Park, {Bo Young}",
note = "Funding Information: At the Department of Plastic and Reconstructive Surgery, Ajou University College of Medicine, in Seoul, South Korea, Hyung Min Hahn, MD, is an Assistant Professor; and Il Jae Lee, PhD, MD, is an Associate Professor. At the Department of Plastic and Reconstructive Surgery, Ewha Womans University School of Medicine, in Seoul, Korea, Kyong-je Woo PhD, MD, is an Assistant Professor; and Bo Young Park, PhD, MD, is Assistant Professor and Chairman. Acknowledgments: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant HI16C0966). The authors have disclosed no other financial relationships related to this article. Submitted September 3, 2019; accepted in revised form October 9, 2018. Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare Republic of Korea (grant HI16C0966). Publisher Copyright: {\textcopyright} 2019 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2019",
month = aug,
day = "1",
doi = "10.1097/01.ASW.0000569116.59534.a6",
language = "English",
volume = "32",
pages = "370--377",
journal = "Advances in Skin and Wound Care",
issn = "1527-7941",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "8",
}