Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

Bang Hyun Kim, Young Suk Won, Dae Yong Kim, Bora Kim, Eun Young Kim, Mijung Yoon, Goo Taeg Oh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Peroxisome proliferator-activated receptor α and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPARα-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E2-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E2-treated group, but interestingly not in PPARα-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E2-treated mice. These novel results suggest the possibility of signaling crosstalk between PPARα and E2, causing obesity in vivo.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalBMB Reports
Volume42
Issue number2
DOIs
StatePublished - Feb 2009

Keywords

  • Estrogen
  • LPL
  • Obesity
  • PPARα
  • Signaling crosstalk

Fingerprint

Dive into the research topics of 'Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity'. Together they form a unique fingerprint.

Cite this