Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

Bang Hyun Kim; Young Suk Won; Dae Yong Kim; Bora Kim; Eun Young Kim; Mijung Yoon; Goo Taeg Oh

doi:10.5483/BMBRep.2009.42.2.091

Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

Bang Hyun Kim, Young Suk Won, Dae Yong Kim, Bora Kim, Eun Young Kim, Mijung Yoon, Goo Taeg Oh

Department of Life Science

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Peroxisome proliferator-activated receptor α and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPARα-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E₂-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E₂-treated group, but interestingly not in PPARα-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E₂-treated mice. These novel results suggest the possibility of signaling crosstalk between PPARα and E₂, causing obesity in vivo.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	BMB Reports
Volume	42
Issue number	2
DOIs	https://doi.org/10.5483/BMBRep.2009.42.2.091
State	Published - Feb 2009

Keywords

Estrogen
LPL
Obesity
PPARα
Signaling crosstalk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5483/BMBRep.2009.42.2.091

Cite this

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abstract = "Peroxisome proliferator-activated receptor α and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPARα-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E2-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E2-treated group, but interestingly not in PPARα-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E2-treated mice. These novel results suggest the possibility of signaling crosstalk between PPARα and E2, causing obesity in vivo.",

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AU - Kim, Eun Young

AU - Yoon, Mijung

AU - Oh, Goo Taeg

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AB - Peroxisome proliferator-activated receptor α and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPARα-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E2-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E2-treated group, but interestingly not in PPARα-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E2-treated mice. These novel results suggest the possibility of signaling crosstalk between PPARα and E2, causing obesity in vivo.

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KW - PPARα

KW - Signaling crosstalk

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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

Abstract

Keywords

UN SDGs

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