Sibutramine (reductil®)-induced cutaneous leukocytoclastic vasculitis: A case report

You Jin Ha, You Jin Han, You Won Choi, Ki Bum Myung, Hae Young Choi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil® , Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine.

Original languageEnglish
Pages (from-to)544-547
Number of pages4
JournalAnnals of Dermatology
Issue number4
StatePublished - Nov 2011


  • Cutaneous leukocytoclastic vasculitis
  • Drug induced vasculitis
  • Sibutramine


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