Shrinky-Dink microfluidics: Rapid generation of deep and rounded patterns

Anthony Grimes, David N. Breslauer, Maureen Long, Jonathan Pegan, Luke P. Lee, Michelle Khine

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


We present a rapid and non-photolithographic approach to microfluidic pattern generation by leveraging the inherent shrinkage properties of biaxially oriented polystyrene thermoplastic sheets. This novel approach yields channels deep enough for mammalian cell assays, with demonstrated heights up to 80 μm. Moreover, we can consistently and easily achieve rounded channels, multi-height channels, and channels as thin as 65 μm in width. Finally, we demonstrate the utility of this simple microfabrication approach by fabricating a functional gradient generator. The whole process-from device design conception to working device-can be completed within minutes.

Original languageEnglish
Pages (from-to)170-172
Number of pages3
JournalLab on a Chip
Issue number1
StatePublished - 2007


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