Sex-chromosome homomorphy in palearctic tree frogs results from both turnovers and X-Y recombination

Christophe Dufresnes, Amael Borzee, Agnes Horn, Matthias Stock, Massimo Ostini, Roberto Sermier, Jerome Wassef, Spartak N. Litvinchuck, Tiffany A. Kosch, Bruce Waldman, Yikweon Jang, Alan Brelsford, Nicolas Perrin

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Contrasting with birds and mammals, poikilothermic vertebrates often have homomorphic sex chromosomes, possibly resulting from high rates of sex-chromosome turnovers and/or occasional X-Y recombination. Strong support for the latter mechanism was provided by four species of European tree frogs, which inherited from a common ancestor (~5Ma) the same pair of homomorphic sex chromosomes (linkage group 1, LG1), harboring the candidate sex-determining gene Dmrt1.Here, we test sex linkage of LG1 across six additional species of the Eurasian Hyla radiation with divergence times ranging from 6 to 40 Ma. LG1 turns out to be sex linked in six of nine resolved cases. Mapping the patterns of sex linkage to the Hyla phylogeny reveals several transitions in sex-determination systems within the last 10My, including one switch in heterogamety. Phylogenetic trees of DNA sequences along LG1 are consistent with occasional X-Y recombination in all species where LG1 is sex linked. These patterns argue against one of the main potential causes for turnovers, namely the accumulation of deleteriousmutations on nonrecombining chromosomes. Sibship analyses show that LG1 recombination is strongly reduced in males from most species investigated, including some in which it is autosomal. Intrinsically low male recombination might facilitate the evolution of male heterogamety, and the presence of important genes from the sex-determination cascade might predispose LG1 to become a sex chromosome.

Original languageEnglish
Pages (from-to)2328-2337
Number of pages10
JournalMolecular Biology and Evolution
Volume32
Issue number9
DOIs
StatePublished - Sep 2015

Keywords

  • DMRT1
  • Fountain of youth hypothesis
  • Hyla
  • Recombination
  • Sex-chromosome transitions

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