Severe glyphosate-surfactant intoxication: Successful treatment with continuous renal replacement therapy

Dong Hoon Lee, Yoon Hee Choi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Glyphosate-surfactant is one of the most commonly used herbicides in the world. Its key component, glyphosate, is a competitive inhibitor of the shikimate pathway, a metabolic pathway found only in plants. However, severe intoxication, including lethal cases by ingestion of, glyphosate-surfactant has been reported. We describe the full recovery of two patients from glyphosate-polyoxyethyleneamine surfactant intoxication and multi-organ system failure following continuous renal replacement therapy. Both patients developed persistent shock, acute kidney injury, lactic acidosis, hyperkalaemia and multi-organ failure despite of resuscitation. We believe that continuous renal replacement therapy should be initiated immediately for removal of glyphosate-polyoxyethyleneamine surfactant in patients with signs of cardiopulmonary compromise, lactic acidosis, and renal failure. We propose the addition of glyphosate-polyoxyethyleneamine surfactant to the list of toxins for which early haemodialysis should be indicated.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalHong Kong Journal of Emergency Medicine
Issue number1
StatePublished - Jan 2017

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  • Glycine
  • Herbicide
  • Human
  • Multiple organ failure
  • Poisoning


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