@article{72b17c75312d452187532d0f1c264c3d,
title = "Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.",
abstract = "One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50values of 18 and 30 μg/mL, respectively.",
keywords = "Ircinia sp., Obesity, PPARδ, Sesquiterpenoids, Sponge",
author = "Dongyup Hahn and Jungwook Chin and Hiyoung Kim and Inho Yang and Won, {Dong Hwan} and Merrick Ekins and Hyukjae Choi and Nam, {Sang Jip} and Heonjoong Kang",
note = "Funding Information: This research was supported by the Marine Biotechnology Program funded by the Ministry of Land, Transport, and Maritime Affairs of Korea and was also supported by the Ewha Global Top5 Grant 2013 of Ewha Womans University. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
doi = "10.1016/j.tetlet.2014.07.019",
language = "English",
volume = "55",
pages = "4716--4719",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "34",
}
