Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.

Dongyup Hahn, Jungwook Chin, Hiyoung Kim, Inho Yang, Dong Hwan Won, Merrick Ekins, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50values of 18 and 30 μg/mL, respectively.

Original languageEnglish
Pages (from-to)4716-4719
Number of pages4
JournalTetrahedron Letters
Volume55
Issue number34
DOIs
StatePublished - 2014

Keywords

  • Ircinia sp.
  • Obesity
  • PPARδ
  • Sesquiterpenoids
  • Sponge

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