Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.

Dongyup Hahn; Jungwook Chin; Hiyoung Kim; Inho Yang; Dong Hwan Won; Merrick Ekins; Hyukjae Choi; Sang Jip Nam; Heonjoong Kang

doi:10.1016/j.tetlet.2014.07.019

Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.

Dongyup Hahn, Jungwook Chin, Hiyoung Kim, Inho Yang, Dong Hwan Won, Merrick Ekins, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC₅₀values of 18 and 30 μg/mL, respectively.

Original language	English
Pages (from-to)	4716-4719
Number of pages	4
Journal	Tetrahedron Letters
Volume	55
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2014.07.019
State	Published - 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.

Keywords

Ircinia sp.
Obesity
PPARδ
Sesquiterpenoids
Sponge

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2014.07.019

Cite this

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title = "Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.",

abstract = "One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50values of 18 and 30 μg/mL, respectively.",

keywords = "Ircinia sp., Obesity, PPARδ, Sesquiterpenoids, Sponge",

author = "Dongyup Hahn and Jungwook Chin and Hiyoung Kim and Inho Yang and Won, {Dong Hwan} and Merrick Ekins and Hyukjae Choi and Nam, {Sang Jip} and Heonjoong Kang",

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T1 - Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.

AU - Hahn, Dongyup

AU - Chin, Jungwook

AU - Kim, Hiyoung

AU - Yang, Inho

AU - Won, Dong Hwan

AU - Ekins, Merrick

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Kang, Heonjoong

PY - 2014

Y1 - 2014

N2 - One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50values of 18 and 30 μg/mL, respectively.

AB - One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50values of 18 and 30 μg/mL, respectively.

KW - Ircinia sp.

KW - Obesity

KW - PPARδ

KW - Sesquiterpenoids

KW - Sponge

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M3 - Article

AN - SCOPUS:84906076403

SN - 0040-4039

VL - 55

SP - 4716

EP - 4719

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.

Abstract

Bibliographical note

Keywords

UN SDGs

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