Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction

Sang Won Han; Tae Jin Song; Cheryl D. Bushnell; Sung Soo Lee; Seo Hyun Kim; Jun Hong Lee; Gyu Sik Kim; Ok Joon Kim; Im Seok Koh; Jong Yun Lee; Seung Han Suk; Sung Ik Lee; Hyo Suk Nam; Kyung Yul Lee; Jae Hyeon Park

doi:10.1111/jon.12308

Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction

Sang Won Han, Tae Jin Song, Cheryl D. Bushnell, Sung Soo Lee, Seo Hyun Kim, Jun Hong Lee, Gyu Sik Kim, Ok Joon Kim, Im Seok Koh, Jong Yun Lee, Seung Han Suk, Sung Ik Lee, Hyo Suk Nam, Kyung Yul Lee, Jae Hyeon Park

Department of Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm³ (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.

Original language	English
Pages (from-to)	351-354
Number of pages	4
Journal	Journal of Neuroimaging
Volume	26
Issue number	3
DOIs	https://doi.org/10.1111/jon.12308
State	Published - 1 May 2016

Bibliographical note

Publisher Copyright:
© 2016 American Society of Neuroimaging.

Keywords

Lacunar infarcts
Uric acid
White matter hyperintensities

Access to Document

10.1111/jon.12308

Cite this

Han, S. W., Song, T. J., Bushnell, C. D., Lee, S. S., Kim, S. H., Lee, J. H., Kim, G. S., Kim, O. J., Koh, I. S., Lee, J. Y., Suk, S. H., Lee, S. I., Nam, H. S., Lee, K. Y., & Park, J. H. (2016). Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction. Journal of Neuroimaging, 26(3), 351-354. https://doi.org/10.1111/jon.12308

@article{9cf0e439403a43c8b8343d48a0bd3295,

title = "Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction",

abstract = "BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm3 (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.",

keywords = "Lacunar infarcts, Uric acid, White matter hyperintensities",

author = "Han, {Sang Won} and Song, {Tae Jin} and Bushnell, {Cheryl D.} and Lee, {Sung Soo} and Kim, {Seo Hyun} and Lee, {Jun Hong} and Kim, {Gyu Sik} and Kim, {Ok Joon} and Koh, {Im Seok} and Lee, {Jong Yun} and Suk, {Seung Han} and Lee, {Sung Ik} and Nam, {Hyo Suk} and Lee, {Kyung Yul} and Park, {Jae Hyeon}",

note = "Publisher Copyright: {\textcopyright} 2016 American Society of Neuroimaging.",

year = "2016",

month = may,

day = "1",

doi = "10.1111/jon.12308",

language = "English",

volume = "26",

pages = "351--354",

journal = "Journal of Neuroimaging",

issn = "1051-2284",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction

AU - Han, Sang Won

AU - Song, Tae Jin

AU - Bushnell, Cheryl D.

AU - Lee, Sung Soo

AU - Kim, Seo Hyun

AU - Lee, Jun Hong

AU - Kim, Gyu Sik

AU - Kim, Ok Joon

AU - Koh, Im Seok

AU - Lee, Jong Yun

AU - Suk, Seung Han

AU - Lee, Sung Ik

AU - Nam, Hyo Suk

AU - Lee, Kyung Yul

AU - Park, Jae Hyeon

PY - 2016/5/1

Y1 - 2016/5/1

N2 - BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm3 (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.

AB - BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm3 (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.

KW - Lacunar infarcts

KW - Uric acid

KW - White matter hyperintensities

UR - http://www.scopus.com/inward/record.url?scp=84964287471&partnerID=8YFLogxK

U2 - 10.1111/jon.12308

DO - 10.1111/jon.12308

M3 - Article

C2 - 26458336

AN - SCOPUS:84964287471

SN - 1051-2284

VL - 26

SP - 351

EP - 354

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

IS - 3

ER -

Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this