Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients

Young Sik Lee, Doug Hyun Han, Chang Moo Jeon, In Kyoon Lyoo, Chul Na, Seok Lae Chae, Soo Churl Cho

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.

Original languageEnglish
Pages (from-to)743-746
Number of pages4
JournalNeuroReport
Volume17
Issue number7
DOIs
StatePublished - May 2006

Keywords

  • Folate
  • Homocysteine
  • Methylenetetrahydrofolate reductase
  • Polymorphism
  • Schizophrenia

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