Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia

J. W. Park; S. H. Park; J. S. Yeom; A. J. Huh; Y. K. Cho; J. Y. Ahn; G. S. Min; G. Y. Song; Y. A. Kim; S. Y. Ahn; S. Y. Woo; B. E. Lee; E. H. Ha; H. S. Han; K. Yoo; J. Y. Seoh

doi:10.1179/000349803235002416

Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia

J. W. Park, S. H. Park, J. S. Yeom, A. J. Huh, Y. K. Cho, J. Y. Ahn, G. S. Min, G. Y. Song, Y. A. Kim, S. Y. Ahn, S. Y. Woo, B. E. Lee, E. H. Ha, H. S. Han, K. Yoo, J. Y. Seoh

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Abstract

One of the peculiar features of Plasmodium vivax malaria in South Korea is the surprisingly high frequency of thrombocytopenia. The mechanism by which this malaria-related thrombocytopenia develops and its role in the pathology, and progress of human infection with P. vivax have not yet been completely understood. In the present study, the serum cytokine profiles of cases of P. vivax malaria who presented with thrombocytopenia were compared with those of similar cases who did not have thrombocytopenia at presentation. The subjects were the 94 consecutive cases of P. vivax malaria who presented at five hospitals in South Korea (all near the Demilitarized Zone) between May 2000 and October 2002, 47 of whom had thrombocytopenia at presentation. When mean values and (S.E.) were compared, the thrombocytopenic patients were found not only to be generally older than the non-thrombocytopenic [25.3 (1.1) v. 21.3 (0.18) years; P < 0.001] but also to have presented with higher serum concentrations of aspartate aminotransferase [77.6 (16.6) v. 32.3 (7.4) U/litre; P < 0.0001], alanine aminotransferase [96.7 (19.0) v. 44.7 (12.0) U/litre; P = 0.0001], interleukin-1 [49.9 (7.4) v. 23.7 (5.1) pg/ml; P < 0.001], interleukin-6 [174.9 (26.4) v. 57.3 (14.6) pg/ml; P = 0.001], interleukin-10 [308.2 (39.6) v. 137.9 (23.1) pg/ml; P < 0.002] and transforming growth factor-β [1134.3 (387.5) v. 416.6 (183.8) pg/ml; P < 0.0001], and higher levels of parasitaemia [4345.7 (966.6) v. 1443.8 (222.7) parasites/μl; P = 0.03). The non-thrombocytopenic patients, however, had relatively high total leucocyte counts [5.8 (0.24) v. 5.4 (0.66) leucocytes/nl; P = 0.03]. The thrombocytopenia associated with P. vivax malaria in South Korea therefore appears to be associated with elevated serum concentrations of both pro- and anti-inflammatory cytokines. To define the role of each cytokine in the development of thrombocytopenia during the course of acute P. vivax malaria, further prospective studies are needed.

Original language	English
Pages (from-to)	339-344
Number of pages	6
Journal	Annals of Tropical Medicine and Parasitology
Volume	97
Issue number	4
DOIs	https://doi.org/10.1179/000349803235002416
State	Published - Jun 2003

Bibliographical note

Funding Information:
This work was supported by the National Nature Science Foundation Committee of China (Grant Nos. 59571014, 59725103, and 59831010) and the Science and Technology Commissions of Shenyang and Liaoning.

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Park, J. W., Park, S. H., Yeom, J. S., Huh, A. J., Cho, Y. K., Ahn, J. Y., Min, G. S., Song, G. Y., Kim, Y. A., Ahn, S. Y., Woo, S. Y., Lee, B. E., Ha, E. H., Han, H. S., Yoo, K., & Seoh, J. Y. (2003). Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia. Annals of Tropical Medicine and Parasitology, 97(4), 339-344. https://doi.org/10.1179/000349803235002416

@article{fb1bde7759734ed0ac1fa2d8086830d1,

title = "Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia",

abstract = "One of the peculiar features of Plasmodium vivax malaria in South Korea is the surprisingly high frequency of thrombocytopenia. The mechanism by which this malaria-related thrombocytopenia develops and its role in the pathology, and progress of human infection with P. vivax have not yet been completely understood. In the present study, the serum cytokine profiles of cases of P. vivax malaria who presented with thrombocytopenia were compared with those of similar cases who did not have thrombocytopenia at presentation. The subjects were the 94 consecutive cases of P. vivax malaria who presented at five hospitals in South Korea (all near the Demilitarized Zone) between May 2000 and October 2002, 47 of whom had thrombocytopenia at presentation. When mean values and (S.E.) were compared, the thrombocytopenic patients were found not only to be generally older than the non-thrombocytopenic [25.3 (1.1) v. 21.3 (0.18) years; P < 0.001] but also to have presented with higher serum concentrations of aspartate aminotransferase [77.6 (16.6) v. 32.3 (7.4) U/litre; P < 0.0001], alanine aminotransferase [96.7 (19.0) v. 44.7 (12.0) U/litre; P = 0.0001], interleukin-1 [49.9 (7.4) v. 23.7 (5.1) pg/ml; P < 0.001], interleukin-6 [174.9 (26.4) v. 57.3 (14.6) pg/ml; P = 0.001], interleukin-10 [308.2 (39.6) v. 137.9 (23.1) pg/ml; P < 0.002] and transforming growth factor-β [1134.3 (387.5) v. 416.6 (183.8) pg/ml; P < 0.0001], and higher levels of parasitaemia [4345.7 (966.6) v. 1443.8 (222.7) parasites/μl; P = 0.03). The non-thrombocytopenic patients, however, had relatively high total leucocyte counts [5.8 (0.24) v. 5.4 (0.66) leucocytes/nl; P = 0.03]. The thrombocytopenia associated with P. vivax malaria in South Korea therefore appears to be associated with elevated serum concentrations of both pro- and anti-inflammatory cytokines. To define the role of each cytokine in the development of thrombocytopenia during the course of acute P. vivax malaria, further prospective studies are needed.",

author = "Park, {J. W.} and Park, {S. H.} and Yeom, {J. S.} and Huh, {A. J.} and Cho, {Y. K.} and Ahn, {J. Y.} and Min, {G. S.} and Song, {G. Y.} and Kim, {Y. A.} and Ahn, {S. Y.} and Woo, {S. Y.} and Lee, {B. E.} and Ha, {E. H.} and Han, {H. S.} and K. Yoo and Seoh, {J. Y.}",

note = "Funding Information: This work was supported by the National Nature Science Foundation Committee of China (Grant Nos. 59571014, 59725103, and 59831010) and the Science and Technology Commissions of Shenyang and Liaoning.",

year = "2003",

month = jun,

doi = "10.1179/000349803235002416",

language = "English",

volume = "97",

pages = "339--344",

journal = "Annals of Tropical Medicine and Parasitology",

issn = "0003-4983",

publisher = "Maney Publishing",

number = "4",

}

Park, JW, Park, SH, Yeom, JS, Huh, AJ, Cho, YK, Ahn, JY, Min, GS, Song, GY, Kim, YA, Ahn, SY, Woo, SY, Lee, BE, Ha, EH, Han, HS, Yoo, K & Seoh, JY 2003, 'Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia', Annals of Tropical Medicine and Parasitology, vol. 97, no. 4, pp. 339-344. https://doi.org/10.1179/000349803235002416

TY - JOUR

T1 - Serum cytokine profiles in patients with Plasmodium vivax malaria

T2 - A comparison between those who presented with and without thrombocytopenia

AU - Park, J. W.

AU - Park, S. H.

AU - Yeom, J. S.

AU - Huh, A. J.

AU - Cho, Y. K.

AU - Ahn, J. Y.

AU - Min, G. S.

AU - Song, G. Y.

AU - Kim, Y. A.

AU - Ahn, S. Y.

AU - Woo, S. Y.

AU - Lee, B. E.

AU - Ha, E. H.

AU - Han, H. S.

AU - Yoo, K.

AU - Seoh, J. Y.

N1 - Funding Information: This work was supported by the National Nature Science Foundation Committee of China (Grant Nos. 59571014, 59725103, and 59831010) and the Science and Technology Commissions of Shenyang and Liaoning.

PY - 2003/6

Y1 - 2003/6

N2 - One of the peculiar features of Plasmodium vivax malaria in South Korea is the surprisingly high frequency of thrombocytopenia. The mechanism by which this malaria-related thrombocytopenia develops and its role in the pathology, and progress of human infection with P. vivax have not yet been completely understood. In the present study, the serum cytokine profiles of cases of P. vivax malaria who presented with thrombocytopenia were compared with those of similar cases who did not have thrombocytopenia at presentation. The subjects were the 94 consecutive cases of P. vivax malaria who presented at five hospitals in South Korea (all near the Demilitarized Zone) between May 2000 and October 2002, 47 of whom had thrombocytopenia at presentation. When mean values and (S.E.) were compared, the thrombocytopenic patients were found not only to be generally older than the non-thrombocytopenic [25.3 (1.1) v. 21.3 (0.18) years; P < 0.001] but also to have presented with higher serum concentrations of aspartate aminotransferase [77.6 (16.6) v. 32.3 (7.4) U/litre; P < 0.0001], alanine aminotransferase [96.7 (19.0) v. 44.7 (12.0) U/litre; P = 0.0001], interleukin-1 [49.9 (7.4) v. 23.7 (5.1) pg/ml; P < 0.001], interleukin-6 [174.9 (26.4) v. 57.3 (14.6) pg/ml; P = 0.001], interleukin-10 [308.2 (39.6) v. 137.9 (23.1) pg/ml; P < 0.002] and transforming growth factor-β [1134.3 (387.5) v. 416.6 (183.8) pg/ml; P < 0.0001], and higher levels of parasitaemia [4345.7 (966.6) v. 1443.8 (222.7) parasites/μl; P = 0.03). The non-thrombocytopenic patients, however, had relatively high total leucocyte counts [5.8 (0.24) v. 5.4 (0.66) leucocytes/nl; P = 0.03]. The thrombocytopenia associated with P. vivax malaria in South Korea therefore appears to be associated with elevated serum concentrations of both pro- and anti-inflammatory cytokines. To define the role of each cytokine in the development of thrombocytopenia during the course of acute P. vivax malaria, further prospective studies are needed.

AB - One of the peculiar features of Plasmodium vivax malaria in South Korea is the surprisingly high frequency of thrombocytopenia. The mechanism by which this malaria-related thrombocytopenia develops and its role in the pathology, and progress of human infection with P. vivax have not yet been completely understood. In the present study, the serum cytokine profiles of cases of P. vivax malaria who presented with thrombocytopenia were compared with those of similar cases who did not have thrombocytopenia at presentation. The subjects were the 94 consecutive cases of P. vivax malaria who presented at five hospitals in South Korea (all near the Demilitarized Zone) between May 2000 and October 2002, 47 of whom had thrombocytopenia at presentation. When mean values and (S.E.) were compared, the thrombocytopenic patients were found not only to be generally older than the non-thrombocytopenic [25.3 (1.1) v. 21.3 (0.18) years; P < 0.001] but also to have presented with higher serum concentrations of aspartate aminotransferase [77.6 (16.6) v. 32.3 (7.4) U/litre; P < 0.0001], alanine aminotransferase [96.7 (19.0) v. 44.7 (12.0) U/litre; P = 0.0001], interleukin-1 [49.9 (7.4) v. 23.7 (5.1) pg/ml; P < 0.001], interleukin-6 [174.9 (26.4) v. 57.3 (14.6) pg/ml; P = 0.001], interleukin-10 [308.2 (39.6) v. 137.9 (23.1) pg/ml; P < 0.002] and transforming growth factor-β [1134.3 (387.5) v. 416.6 (183.8) pg/ml; P < 0.0001], and higher levels of parasitaemia [4345.7 (966.6) v. 1443.8 (222.7) parasites/μl; P = 0.03). The non-thrombocytopenic patients, however, had relatively high total leucocyte counts [5.8 (0.24) v. 5.4 (0.66) leucocytes/nl; P = 0.03]. The thrombocytopenia associated with P. vivax malaria in South Korea therefore appears to be associated with elevated serum concentrations of both pro- and anti-inflammatory cytokines. To define the role of each cytokine in the development of thrombocytopenia during the course of acute P. vivax malaria, further prospective studies are needed.

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U2 - 10.1179/000349803235002416

DO - 10.1179/000349803235002416

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C2 - 12831519

AN - SCOPUS:0037899490

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VL - 97

SP - 339

EP - 344

JO - Annals of Tropical Medicine and Parasitology

JF - Annals of Tropical Medicine and Parasitology

IS - 4

ER -

Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia

Abstract

Bibliographical note

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