TY - JOUR
T1 - Serum 25-hydroxyVitamin D levels and dry eye syndrome
T2 - Differential effects of Vitamin D on ocular diseases
AU - The Epidemiologic Survey Committee of the Korean Ophthalmologic Society
AU - Jee, Donghyun
AU - Kang, Seungbum
AU - Yuan, Changzheng
AU - Cho, Eunyoung
AU - Arroyo, Jorge G.
AU - Kang, Se Woong
AU - Baek, Seung Hee
AU - Kim, Chan Yun
AU - Kim, Sang Duck
AU - Kim, Seung Hyun
AU - Lee, Jong Soo
AU - Lim, Key Hwan
AU - Park, Ki Ho
AU - Park, Young Jeung
AU - Shin, Jae Pil
AU - Song, Su Jeong
AU - Yang, Suk Woo
AU - Yoon, Kyung Chul
AU - Yu, Seung Young
N1 - Funding Information:
The authors would like to express their appreciation of the Epidemiologic Survey Committee of the Korean Ophthalmologic Society for conducting the KNHANES examinations and for supplying the data for this study. The authors wish to acknowledge the financial support of the St.Vincent’s hospital, research institute of medical science (SVHR-2013-12). The Epidemiologic Survey Committee of the Korean Ophthalmologic Society, the members are:
Publisher Copyright:
Copyright © 2016 Jee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/2
Y1 - 2016/2
N2 - Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95%CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95% CI: 0.30-1.64) and cataract (OR = 0.76, 95% CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95% CI: 0.18-0.76) and late AMD (OR = 0.32, 95% CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.
AB - Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95%CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95% CI: 0.30-1.64) and cataract (OR = 0.76, 95% CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95% CI: 0.18-0.76) and late AMD (OR = 0.32, 95% CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.
UR - http://www.scopus.com/inward/record.url?scp=84960517022&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0149294
DO - 10.1371/journal.pone.0149294
M3 - Article
C2 - 26894581
AN - SCOPUS:84960517022
SN - 1932-6203
VL - 11
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e0149294
ER -