Serotype distribution and antimicrobial susceptibilities of invasive Streptococcus pneumoniae isolates from adults in Korea from 1997 to 2012

Chung Jong Kim, Jin Su Song, Su Jin Choi, Kyoung Ho Song, Pyeong Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam Joong Kim, Eui Chong Kim, Myoung don Oh

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In Republic of Korea, a 7-valent pneumococcal conjugated vaccine (PCV7) was licensed for use in infants in 2003, and 13-valent PCV (PCV13) replaced it since 2010. We investigated trends in serotype distribution and antibiotic susceptibility of pneumococcal isolates from adult patients with invasive pneumococcal diseases (IPD). Invasive pneumococcal isolates from adult patients of ≥ 16 years of age were collected from 1997 to 2012. Serotypes of the isolates were determined by the Quellung reaction. Distribution of serotypes was analyzed according to the vaccine types. Antibiotic susceptibility was tested by using E-test strips. A total of 272 invasive pneumococcal isolates were included. The most common serotypes were serotype 19F (8.5%, 23/272), and serotype 3 (8.1%, 22/272), and 24.6% (67/272) of the isolates were of non-vaccine serotypes. Of the 272 isolates, 2.6% (7/272) were penicillin MICs of ≥ 4 μg/mL. The proportion of the PCV13 serotypes decreased from 63.3% (50/79) in 1997-2003 to 48.6% (17/35) in 2011-2012, whereas that of non-vaccine serotypes was 26.6% (21/79) and 25.7% (9/35), respectively, for the same periods. The proportion of the PCV13 serotypes showed a decreasing trend among adult patients with IPD over the study period.

Original languageEnglish
Pages (from-to)715-723
Number of pages9
JournalJournal of Korean Medical Science
Volume31
Issue number5
DOIs
StatePublished - 1 May 2016

Keywords

  • Microbial Sensitivity Tests
  • Pneumococcal vaccines
  • Serotypes
  • Streptococcus pneumoniae

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