Self-assembly of DNA-coupled semiconducting block copolymers

Amanda C. Kamps; Ma Helen M. Cativo; Xi Jun Chen; So Jung Park

doi:10.1021/ma500509u

Self-assembly of DNA-coupled semiconducting block copolymers

Amanda C. Kamps, Ma Helen M. Cativo, Xi Jun Chen, So Jung Park

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We describe the synthesis and self-assembly of amphiphilic semiconducting polymers composed of a polythiophene derivative (i.e., poly[3-(2,5,8,11- tetraoxatridecanyl)thiophene] (PTOTT)) and an oligonucleotide, DNA-b-PTOTT. These new bioconjugated polymers combine the excellent optoelectronic properties of semiconducting polymers and the programmable molecular recognition properties of DNA. Because of the unique combination of rigid polythiophene and highly negatively charged DNA, they self-assemble into size-controllable vesicles in water. DNA-modified one-dimensional polythiophene nanoribbons were formed by simultaneous assembly of DNA-b-PTOTT with PEG-b-PTOTT, demonstrating that various types of DNA-modified functional nanostructures can be formed by the mixed assembly. This approach offers a new pathway to couple various types of soft optoelectronic nanostructures with DNAs molecular recognition properties.

Original language	English
Pages (from-to)	3720-3726
Number of pages	7
Journal	Macromolecules
Volume	47
Issue number	11
DOIs	https://doi.org/10.1021/ma500509u
State	Published - 10 Jun 2014

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AU - Kamps, Amanda C.

AU - Cativo, Ma Helen M.

AU - Chen, Xi Jun

AU - Park, So Jung

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AB - We describe the synthesis and self-assembly of amphiphilic semiconducting polymers composed of a polythiophene derivative (i.e., poly[3-(2,5,8,11- tetraoxatridecanyl)thiophene] (PTOTT)) and an oligonucleotide, DNA-b-PTOTT. These new bioconjugated polymers combine the excellent optoelectronic properties of semiconducting polymers and the programmable molecular recognition properties of DNA. Because of the unique combination of rigid polythiophene and highly negatively charged DNA, they self-assemble into size-controllable vesicles in water. DNA-modified one-dimensional polythiophene nanoribbons were formed by simultaneous assembly of DNA-b-PTOTT with PEG-b-PTOTT, demonstrating that various types of DNA-modified functional nanostructures can be formed by the mixed assembly. This approach offers a new pathway to couple various types of soft optoelectronic nanostructures with DNAs molecular recognition properties.

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Self-assembly of DNA-coupled semiconducting block copolymers

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