Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding properties

Xi Jun Chen; Brenda L. Sanchez-Gaytan; Sara E.N. Hayik; Michael Fryd; Bradford B. Wayland; So Jung Park

doi:10.1002/smll.201001185

Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding properties

Xi Jun Chen
, Brenda L. Sanchez-Gaytan
, Sara E.N. Hayik
, Michael Fryd
, Bradford B. Wayland
, So Jung Park

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The self-assembly of DNA block-copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.

Original language	English
Pages (from-to)	2256-2260
Number of pages	5
Journal	Small
Volume	6
Issue number	20
DOIs	https://doi.org/10.1002/smll.201001185
State	Published - 18 Oct 2010

Keywords

DNA block-copolymers
DNA detection
Nanoparticles
Self-assembly

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10.1002/smll.201001185

Cite this

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title = "Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding properties",

abstract = "The self-assembly of DNA block-copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.",

keywords = "DNA block-copolymers, DNA detection, Nanoparticles, Self-assembly",

author = "Chen, \{Xi Jun\} and Sanchez-Gaytan, \{Brenda L.\} and Hayik, \{Sara E.N.\} and Michael Fryd and Wayland, \{Bradford B.\} and Park, \{So Jung\}",

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AU - Chen, Xi Jun

AU - Sanchez-Gaytan, Brenda L.

AU - Hayik, Sara E.N.

AU - Fryd, Michael

AU - Wayland, Bradford B.

AU - Park, So Jung

PY - 2010/10/18

Y1 - 2010/10/18

N2 - The self-assembly of DNA block-copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.

AB - The self-assembly of DNA block-copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.

KW - DNA block-copolymers

KW - DNA detection

KW - Nanoparticles

KW - Self-assembly

UR - https://www.scopus.com/pages/publications/78349276586

U2 - 10.1002/smll.201001185

DO - 10.1002/smll.201001185

M3 - Article

C2 - 20830717

AN - SCOPUS:78349276586

SN - 1613-6810

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SP - 2256

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JO - Small

JF - Small

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ER -

Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding properties

Abstract

Keywords

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