Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding properties

Xi Jun Chen, Brenda L. Sanchez-Gaytan, Sara E.N. Hayik, Michael Fryd, Bradford B. Wayland, So Jung Park

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The self-assembly of DNA block-copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.

Original languageEnglish
Pages (from-to)2256-2260
Number of pages5
JournalSmall
Volume6
Issue number20
DOIs
StatePublished - 18 Oct 2010

Keywords

  • DNA block-copolymers
  • DNA detection
  • Nanoparticles
  • Self-assembly

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