Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Cheol Am Hong; Bora Jang; Eun Hye Jeong; Hansaem Jeong; Hyukjin Lee

doi:10.1039/c4cc03834g

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Cheol Am Hong
, Bora Jang
, Eun Hye Jeong
, Hansaem Jeong
, Hyukjin Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

Original language	English
Pages (from-to)	13049-13051
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	86
DOIs	https://doi.org/10.1039/c4cc03834g
State	Published - 2 Oct 2014

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10.1039/c4cc03834g

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abstract = "Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.",

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AU - Hong, Cheol Am

AU - Jang, Bora

AU - Jeong, Eun Hye

AU - Jeong, Hansaem

AU - Lee, Hyukjin

PY - 2014/10/2

Y1 - 2014/10/2

N2 - Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

AB - Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

UR - https://www.scopus.com/pages/publications/84907788296

U2 - 10.1039/c4cc03834g

DO - 10.1039/c4cc03834g

M3 - Article

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VL - 50

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EP - 13051

JO - Chemical Communications

JF - Chemical Communications

IS - 86

ER -

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Abstract

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