Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Cheol Am Hong, Bora Jang, Eun Hye Jeong, Hansaem Jeong, Hyukjin Lee

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

Original languageEnglish
Pages (from-to)13049-13051
Number of pages3
JournalChemical Communications
Volume50
Issue number86
DOIs
StatePublished - 2 Oct 2014

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