Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Cheol Am Hong; Bora Jang; Eun Hye Jeong; Hansaem Jeong; Hyukjin Lee

doi:10.1039/c4cc03834g

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Cheol Am Hong, Bora Jang, Eun Hye Jeong, Hansaem Jeong, Hyukjin Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

Original language	English
Pages (from-to)	13049-13051
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	86
DOIs	https://doi.org/10.1039/c4cc03834g
State	Published - 2 Oct 2014

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abstract = "Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.",

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AU - Hong, Cheol Am

AU - Jang, Bora

AU - Jeong, Eun Hye

AU - Jeong, Hansaem

AU - Lee, Hyukjin

PY - 2014/10/2

Y1 - 2014/10/2

N2 - Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

AB - Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

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JO - Chemical Communications

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Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Abstract

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