Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents

Pramod K. Sahu; Tamima Umme; Jinha Yu; Akshata Nayak; Gyudong Kim; Minsoo Noh; Jae Young Lee; Dae Duk Kim; Lak Shin Jeong

doi:10.1021/acs.jmedchem.5b00804

Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents

Pramod K. Sahu, Tamima Umme, Jinha Yu, Akshata Nayak, Gyudong Kim, Minsoo Noh, Jae Young Lee, Dae Duk Kim, Lak Shin Jeong

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.

Original language	English
Pages (from-to)	8734-8738
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	58
Issue number	21
DOIs	https://doi.org/10.1021/acs.jmedchem.5b00804
State	Published - 13 Oct 2015

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© 2015 American Chemical Society.

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title = "Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents",

abstract = "On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.",

author = "Sahu, {Pramod K.} and Tamima Umme and Jinha Yu and Akshata Nayak and Gyudong Kim and Minsoo Noh and Lee, {Jae Young} and Kim, {Dae Duk} and Jeong, {Lak Shin}",

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T1 - Selenoacyclovir and Selenoganciclovir

T2 - Discovery of a New Template for Antiviral Agents

AU - Sahu, Pramod K.

AU - Umme, Tamima

AU - Yu, Jinha

AU - Nayak, Akshata

AU - Kim, Gyudong

AU - Noh, Minsoo

AU - Lee, Jae Young

AU - Kim, Dae Duk

AU - Jeong, Lak Shin

PY - 2015/10/13

Y1 - 2015/10/13

N2 - On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.

AB - On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.

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JO - Journal of Medicinal Chemistry

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IS - 21

ER -

Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents

Abstract

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