Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents

Pramod K. Sahu, Tamima Umme, Jinha Yu, Akshata Nayak, Gyudong Kim, Minsoo Noh, Jae Young Lee, Dae Duk Kim, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.

Original languageEnglish
Pages (from-to)8734-8738
Number of pages5
JournalJournal of Medicinal Chemistry
Volume58
Issue number21
DOIs
StatePublished - 13 Oct 2015

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