Selenium attenuates Aβ production and Aβ-induced neuronal death

A. Ryeong Gwon, Jong Sung Park, Jun Hyung Park, Sang Ha Baik, Hye Young Jeong, Dong Hoon Hyun, Kye Won Park, Dong Gyu Jo

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The objective of the present study was to examine the role of selenium in the metabolism of Aβ and in Aβ-induced neuronal death. Selenium treatment significantly reduced Aβ40, Aβ42, and sAPPβ production by reducing Aβ producing β-secretase and γ-secretase activities. The lipid peroxidation product 4-Hydroxynonenal (HNE)-induced transcription of β-secretase (BACE1) was blocked by selenium. Finally, our data show that selenium protects against HNE and Aβ-mediated toxicity in primary cultured neurons. The present study suggests that selenium may be able to salvage the neuronal degeneration of Alzheimer's disease, thereby limiting β-amyloid production and neuronal death.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalNeuroscience Letters
Volume469
Issue number3
DOIs
StatePublished - 29 Jan 2010

Keywords

  • 4-Hydroxynonenal
  • Alzheimer's disease
  • BACE1
  • Lipid peroxidation
  • Selenium

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