Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells

Esma Ucar; Ozlem Seven; Dayoung Lee; Gyoungmi Kim; Juyoung Yoon; Engin U. Akkaya

doi:10.1002/cptc.201800231

Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells

Esma Ucar, Ozlem Seven, Dayoung Lee, Gyoungmi Kim, Juyoung Yoon, Engin U. Akkaya

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Among the pathways for improving the practice of photodynamic therapy of cancer, increasing the selectivity of photodynamic action is an obvious choice. Considering the different characteristics of mitochondria in normal cells and cancer cells, we designed mitochondria-targeting photosensitizers. We now demonstrate for the first time that mitochondria-targeted photosensitizers by triphenylphosphonium (TPP) derivatization are more selective for cancer cells compared to normal cells, presumably due to the larger membrane potential of cancer-cell mitochondria allowing more efficient accumulation of the photosensitizer.

Original language	English
Pages (from-to)	129-132
Number of pages	4
Journal	ChemPhotoChem
Volume	3
Issue number	3
DOIs	https://doi.org/10.1002/cptc.201800231
State	Published - 1 Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

cytotoxicity
organelles
photodynamic therapy
photosensitizers
singlet oxygen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cptc.201800231

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title = "Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells",

abstract = "Among the pathways for improving the practice of photodynamic therapy of cancer, increasing the selectivity of photodynamic action is an obvious choice. Considering the different characteristics of mitochondria in normal cells and cancer cells, we designed mitochondria-targeting photosensitizers. We now demonstrate for the first time that mitochondria-targeted photosensitizers by triphenylphosphonium (TPP) derivatization are more selective for cancer cells compared to normal cells, presumably due to the larger membrane potential of cancer-cell mitochondria allowing more efficient accumulation of the photosensitizer.",

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AU - Ucar, Esma

AU - Seven, Ozlem

AU - Lee, Dayoung

AU - Kim, Gyoungmi

AU - Yoon, Juyoung

AU - Akkaya, Engin U.

PY - 2019/3/1

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AB - Among the pathways for improving the practice of photodynamic therapy of cancer, increasing the selectivity of photodynamic action is an obvious choice. Considering the different characteristics of mitochondria in normal cells and cancer cells, we designed mitochondria-targeting photosensitizers. We now demonstrate for the first time that mitochondria-targeted photosensitizers by triphenylphosphonium (TPP) derivatization are more selective for cancer cells compared to normal cells, presumably due to the larger membrane potential of cancer-cell mitochondria allowing more efficient accumulation of the photosensitizer.

KW - cytotoxicity

KW - organelles

KW - photodynamic therapy

KW - photosensitizers

KW - singlet oxygen

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ER -

Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells

Abstract

Bibliographical note

Keywords

UN SDGs

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