Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells

Esma Ucar, Ozlem Seven, Dayoung Lee, Gyoungmi Kim, Juyoung Yoon, Engin U. Akkaya

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Among the pathways for improving the practice of photodynamic therapy of cancer, increasing the selectivity of photodynamic action is an obvious choice. Considering the different characteristics of mitochondria in normal cells and cancer cells, we designed mitochondria-targeting photosensitizers. We now demonstrate for the first time that mitochondria-targeted photosensitizers by triphenylphosphonium (TPP) derivatization are more selective for cancer cells compared to normal cells, presumably due to the larger membrane potential of cancer-cell mitochondria allowing more efficient accumulation of the photosensitizer.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalChemPhotoChem
Volume3
Issue number3
DOIs
StatePublished - 1 Mar 2019

Keywords

  • cytotoxicity
  • organelles
  • photodynamic therapy
  • photosensitizers
  • singlet oxygen

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