Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Hye Yeon Lee, Yoon Pyo Choi, Sunkyung Kim, Taejin Yoon, Zhiqian Guo, Songyi Lee, K. M.K. Swamy, Gyoungmi Kim, Jin Yong Lee, Injae Shin, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

Original languageEnglish
Pages (from-to)6967-6969
Number of pages3
JournalChemical Communications
Issue number53
StatePublished - 3 Jun 2014


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