In this paper, we report a new pyrene imine derivative which bears a relatively rigid intramolecular hydrogen bonding pocket, for fluorescent and colorimetric sensing of cyanide. In CH3CN solution, the chemosensor displayed distinct fluorescent and UV absorption changes towards CN-, CH3CO2-, F-, and H2PO4-. Notably, in an aqueous CH3CN medium (10%, v/v), the selectivity towards cyanide over other various anions were observed with an obvious fluorescence enhancement and colorimetric change. Thus, we demonstrated that the selectivity of the pyrene based chemosensor towards anions can be optimized via controlling hydrogen bonding interactions in different solvent systems. Finally the application of the chemosensor in fluorescent imaging cellular cyanide variation was demonstrated with living HeLa cells.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A3A2048814 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.
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- Cell imaging
- Colorimetric sensor
- Cyanide sensor
- Fluorescent sensor
- Hydrogen bonding