Screening ultrasound in women with negative mammography: Outcome analysis

Ji Young Hwang, Boo Kyung Han, Eun Young Ko, Jung Hee Shin, Soo Yeon Hahn, Mee Young Nam

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Purpose: To show the results of an audit of screening breast ultrasound (US) in women with negative mammography in a single institution and to analyze US-detected cancers within a year and interval cancers. Materials and Methods: During the year of 2006, 1974 women with negative mammography were screened with US in our screening center, and 1727 among them had pathologic results or any follow up breast examinations more than a year. We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up. Results: Among 1727 women (age, 30–76 years, median 49.5 years), 1349 women (78.1%) showed dense breasts on mammography, 762 (44.1%) had previous breast US, and 25 women (1.4%) had a personal history of breast cancers. Test negatives were 94.2% (1.627/1727) [BI-RADS category 1 in 885 (51.2%), 2 in 742 (43.0%)]. The recall rate (=BI-RADS category 3, 4, 5) was 5.8%. Eight cancers were additionally detected with US (yield, 4.6 per 1000). The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively. Eight of nine true positive cancers were stage I or in-situ cancers. One interval cancer was stage I cancer from BI-RADS category 2. Conclusion: Screening US detected 4.6 additional cancers among 1000. The recall rate was 5.8%, which is in lower bound of acceptable range of mammography (5–12%), according to American College of Radiology standard.

Original languageEnglish
Pages (from-to)1352-1358
Number of pages7
JournalYonsei Medical Journal
Volume56
Issue number5
DOIs
StatePublished - 1 Sep 2015

Keywords

  • Breast neoplasms
  • Breast neoplasms
  • Cancer screening
  • Diagnosis
  • Ultrasonography

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