Scanning magnetoresistance microscopy for imaging magnetically labeled DNA microarrays

Mei Lin Chan; Gerardo Jaramillo; Ahjeong Son; Krassimira R. Hristova; David A. Horsley

doi:10.1109/TMAG.2009.2024876

Scanning magnetoresistance microscopy for imaging magnetically labeled DNA microarrays

Mei Lin Chan, Gerardo Jaramillo, Ahjeong Son, Krassimira R. Hristova, David A. Horsley

Environmental Science & Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We demonstrate the use of a magnetic tunnel junction (MTJ) sensor as a probe for non-contact scanning microscopy of magnetically labeled DNA microarrays. Induced magnetic stray fields from 2.8 μm diameter magnetic particles are detected using the MTJ sensor, while two dimensional scanning generates the magnetic map of the DNA microarray with a spatial resolution of 1 μm over a large scan area exceeding 1 cm². Current particle-sensor spacing of ∼20 μm results in a detection resolution of ∼30 magnetic particles within each 100 μm diameter DNA spot. Our results highlight the use of scanning magnetoresistive microscopy as a convenient and powerful technique for the accurate detection and identification of biomolecules tagged with magnetic particles.

Original language	English
Article number	5257293
Pages (from-to)	4816-4820
Number of pages	5
Journal	IEEE Transactions on Magnetics
Volume	45
Issue number	10
DOIs	https://doi.org/10.1109/TMAG.2009.2024876
State	Published - Oct 2009

Keywords

Biosensor
DNA microarray
Magnetic imaging
Magnetic tunnel junction (MTJ

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10.1109/TMAG.2009.2024876

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title = "Scanning magnetoresistance microscopy for imaging magnetically labeled DNA microarrays",

abstract = "We demonstrate the use of a magnetic tunnel junction (MTJ) sensor as a probe for non-contact scanning microscopy of magnetically labeled DNA microarrays. Induced magnetic stray fields from 2.8 μm diameter magnetic particles are detected using the MTJ sensor, while two dimensional scanning generates the magnetic map of the DNA microarray with a spatial resolution of 1 μm over a large scan area exceeding 1 cm2. Current particle-sensor spacing of ∼20 μm results in a detection resolution of ∼30 magnetic particles within each 100 μm diameter DNA spot. Our results highlight the use of scanning magnetoresistive microscopy as a convenient and powerful technique for the accurate detection and identification of biomolecules tagged with magnetic particles.",

keywords = "Biosensor, DNA microarray, Magnetic imaging, Magnetic tunnel junction (MTJ",

author = "Chan, {Mei Lin} and Gerardo Jaramillo and Ahjeong Son and Hristova, {Krassimira R.} and Horsley, {David A.}",

note = "Funding Information: This work was supported in part by the National Science Foundation under Grant No. ECCS 0601383. The authors would like to thank J. Pfeiff from the Arraycore Facility at UC Davis for the DNA microarray printing as well as Micromagnetics Inc. for valuable discussions.",

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doi = "10.1109/TMAG.2009.2024876",

language = "English",

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journal = "IEEE Transactions on Magnetics",

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AU - Chan, Mei Lin

AU - Jaramillo, Gerardo

AU - Son, Ahjeong

AU - Hristova, Krassimira R.

AU - Horsley, David A.

N1 - Funding Information: This work was supported in part by the National Science Foundation under Grant No. ECCS 0601383. The authors would like to thank J. Pfeiff from the Arraycore Facility at UC Davis for the DNA microarray printing as well as Micromagnetics Inc. for valuable discussions.

PY - 2009/10

Y1 - 2009/10

N2 - We demonstrate the use of a magnetic tunnel junction (MTJ) sensor as a probe for non-contact scanning microscopy of magnetically labeled DNA microarrays. Induced magnetic stray fields from 2.8 μm diameter magnetic particles are detected using the MTJ sensor, while two dimensional scanning generates the magnetic map of the DNA microarray with a spatial resolution of 1 μm over a large scan area exceeding 1 cm2. Current particle-sensor spacing of ∼20 μm results in a detection resolution of ∼30 magnetic particles within each 100 μm diameter DNA spot. Our results highlight the use of scanning magnetoresistive microscopy as a convenient and powerful technique for the accurate detection and identification of biomolecules tagged with magnetic particles.

AB - We demonstrate the use of a magnetic tunnel junction (MTJ) sensor as a probe for non-contact scanning microscopy of magnetically labeled DNA microarrays. Induced magnetic stray fields from 2.8 μm diameter magnetic particles are detected using the MTJ sensor, while two dimensional scanning generates the magnetic map of the DNA microarray with a spatial resolution of 1 μm over a large scan area exceeding 1 cm2. Current particle-sensor spacing of ∼20 μm results in a detection resolution of ∼30 magnetic particles within each 100 μm diameter DNA spot. Our results highlight the use of scanning magnetoresistive microscopy as a convenient and powerful technique for the accurate detection and identification of biomolecules tagged with magnetic particles.

KW - Biosensor

KW - DNA microarray

KW - Magnetic imaging

KW - Magnetic tunnel junction (MTJ

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JO - IEEE Transactions on Magnetics

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Scanning magnetoresistance microscopy for imaging magnetically labeled DNA microarrays

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Keywords

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