Scandium(III) triflate-catalyzed coumarin synthesis

Keumnyeo Jung; Yun Jeong Park; Jae Sang Ryu

doi:10.1080/00397910802369513

Scandium(III) triflate-catalyzed coumarin synthesis

Keumnyeo Jung, Yun Jeong Park, Jae Sang Ryu

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Scandium(III) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10 mol% scandium(III) triflate at 80°C. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup.

Original language	English
Pages (from-to)	4395-4406
Number of pages	12
Journal	Synthetic Communications
Volume	38
Issue number	24
DOIs	https://doi.org/10.1080/00397910802369513
State	Published - Jan 2008

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-331-E00438) and the second stage of the Brain Korea 21 Project.

Keywords

Coumarins
Pechmann reaction
Phenols
Sc(OTf)
Solvent-free

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10.1080/00397910802369513

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title = "Scandium(III) triflate-catalyzed coumarin synthesis",

abstract = "Scandium(III) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10 mol\% scandium(III) triflate at 80°C. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup.",

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author = "Keumnyeo Jung and Park, \{Yun Jeong\} and Ryu, \{Jae Sang\}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-331-E00438) and the second stage of the Brain Korea 21 Project.",

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doi = "10.1080/00397910802369513",

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T1 - Scandium(III) triflate-catalyzed coumarin synthesis

AU - Jung, Keumnyeo

AU - Park, Yun Jeong

AU - Ryu, Jae Sang

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-331-E00438) and the second stage of the Brain Korea 21 Project.

PY - 2008/1

Y1 - 2008/1

N2 - Scandium(III) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10 mol% scandium(III) triflate at 80°C. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup.

AB - Scandium(III) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10 mol% scandium(III) triflate at 80°C. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup.

KW - Coumarins

KW - Pechmann reaction

KW - Phenols

KW - Sc(OTf)

KW - Solvent-free

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DO - 10.1080/00397910802369513

M3 - Article

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SN - 0039-7911

VL - 38

SP - 4395

EP - 4406

JO - Synthetic Communications

JF - Synthetic Communications

IS - 24

ER -

Scandium(III) triflate-catalyzed coumarin synthesis

Abstract

Bibliographical note

Keywords

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